The Effect of a General Healthy Lifestyle Intervention Delivered Around Pregnancy on Gestational Weight Gain and Infant Growth

William J. Heerman; Lauren R. Samuels; Lauren Barr; Laura E. Burgess; Katherine E. Hartmann; Shari L. Barkin

doi:10.1007/s10995-020-02998-0

The Effect of a General Healthy Lifestyle Intervention Delivered Around Pregnancy on Gestational Weight Gain and Infant Growth

William J. Heerman, Lauren R. Samuels, Lauren Barr, Laura E. Burgess, Katherine E. Hartmann, Shari L. Barkin

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objectives: A life-course perspective emphasizes healthy behaviors before, during, and after pregnancy to support a multi-generational risk reduction in obesity for mothers and infants. Optimal timing, content, and dose of such interventions is not well defined. Methods: We conducted a nested cohort within a randomized trial to evaluate whether a healthy lifestyle intervention around pregnancy led to a “spill-over effect,” including a healthier rate (kg/week) of maternal gestational weight gain, and infant growth during the first year. Study enrollment began in 2012, follow-up data collection completed in 2018, and the data were analyzed in 2019. The intervention focused on healthy maternal diet and physical activity but not pregnancy weight or infant feeding. Outcome data were abstracted from electronic medical records. Results: Of the 165 women who became pregnant, 114 enrolled in the nested cohort. The average pre-pregnancy BMI was 29.6 (SD 5.1) kg/m². Mixed effects models suggested clinically insignificant differences in both the rate of gestational weight gain (-0.02 kg/week; 95% CI -0.09, 0.06) and the rate of infant growth (difference at 1 year: -0.002 kg/cm; 95% CI -0.009, 0.005). Conclusions for Practice: A behavioral intervention that focused on overall maternal health delivered in the time around pregnancy did not result in a “spill-over effect” on healthy gestational weight gain or healthy infant growth during the first year of life. Trial Registration: This study is registered at www.clinicaltrials.gov NCT01316653.

Original language	English
Pages (from-to)	1404-1411
Number of pages	8
Journal	Maternal and Child Health Journal
Volume	24
Issue number	11
DOIs	https://doi.org/10.1007/s10995-020-02998-0
State	Published - Nov 1 2020

Bibliographical note

Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Funding

We would like to acknowledge Carrie Gibson, RN for her role in conducting the chart abstractions from participant medical records. Research presented in this paper is that of the authors and does not reflect the official policy of the National Institute of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI). This study was supported by a K23 from NHLBI (K23 HL127104). The REDCap Database is supported by NCATS/NIH, (UL1 TR000445). The original GROW trial was supported by grants (U01 HL103620, U01 HL103561, NIH DK056350) with additional support from the remaining members of the COPTR Consortium (U01 HD068890, U01 HL103622, U01 HL103629), from the National Heart, Lung, and Blood Institute; the Eunice Kennedy Shriver National Institute of Child Health and Development; and the Office of Behavioral and Social Sciences Research. We would like to acknowledge Carrie Gibson, RN for her role in conducting the chart abstractions from participant medical records. Research presented in this paper is that of the authors and does not reflect the official policy of the National Institute of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI). This study was supported by a K23 from NHLBI (K23 HL127104). The REDCap Database is supported by NCATS/NIH, (UL1 TR000445). The original GROW trial was supported by grants (U01 HL103620, U01 HL103561, NIH DK056350) with additional support from the remaining members of the COPTR Consortium (U01 HD068890, U01 HL103622, U01 HL103629), from the National Heart, Lung, and Blood Institute; the Eunice Kennedy Shriver National Institute of Child Health and Development; and the Office of Behavioral and Social Sciences Research.

Funders	Funder number
COPTR Consortium	U01 HD068890, U01 HL103622, U01 HL103629
NIH NCATS
National Institutes of Health/National Institute of Environmental Health Sciences
National Institutes of Health (NIH)	DK056350, U01 HL103561, UL1 TR000445, U01 HL103620
National Heart, Lung, and Blood Institute (NHLBI)	U01HL103622, K23 HL127104
Office of Behavioral and Social Sciences Research
National Center for Advancing Translational Sciences (NCATS)
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Keywords

Behavioral intervention
Gestational weight gain
Infancy
Obesity
Pregnancy

ASJC Scopus subject areas

Epidemiology
Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10995-020-02998-0

Cite this

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title = "The Effect of a General Healthy Lifestyle Intervention Delivered Around Pregnancy on Gestational Weight Gain and Infant Growth",

abstract = "Objectives: A life-course perspective emphasizes healthy behaviors before, during, and after pregnancy to support a multi-generational risk reduction in obesity for mothers and infants. Optimal timing, content, and dose of such interventions is not well defined. Methods: We conducted a nested cohort within a randomized trial to evaluate whether a healthy lifestyle intervention around pregnancy led to a “spill-over effect,” including a healthier rate (kg/week) of maternal gestational weight gain, and infant growth during the first year. Study enrollment began in 2012, follow-up data collection completed in 2018, and the data were analyzed in 2019. The intervention focused on healthy maternal diet and physical activity but not pregnancy weight or infant feeding. Outcome data were abstracted from electronic medical records. Results: Of the 165 women who became pregnant, 114 enrolled in the nested cohort. The average pre-pregnancy BMI was 29.6 (SD 5.1) kg/m2. Mixed effects models suggested clinically insignificant differences in both the rate of gestational weight gain (-0.02 kg/week; 95\% CI -0.09, 0.06) and the rate of infant growth (difference at 1 year: -0.002 kg/cm; 95\% CI -0.009, 0.005). Conclusions for Practice: A behavioral intervention that focused on overall maternal health delivered in the time around pregnancy did not result in a “spill-over effect” on healthy gestational weight gain or healthy infant growth during the first year of life. Trial Registration: This study is registered at www.clinicaltrials.gov NCT01316653.",

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AU - Burgess, Laura E.

AU - Hartmann, Katherine E.

AU - Barkin, Shari L.

PY - 2020/11/1

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The Effect of a General Healthy Lifestyle Intervention Delivered Around Pregnancy on Gestational Weight Gain and Infant Growth

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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