The effect of anti-IFN-γ antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice

Y. Suzuki, J. S. Remington

Research output: Contribution to journalArticlepeer-review

148 Scopus citations

Abstract

The effect of an IFN-γ-mAb on the protective activity of immune T cells against Toxoplasma infection was examined in a murine model of toxoplasmosis. Mice that received anti-IFN-γ antibody and immune spleen cells all died of toxoplasmosis after challenge with Toxoplasma tachyzoites. In contrast, mice that received normal IgG and immune spleen cells all survived the infection. The protective activity of Lyt-2+ immune T cells, previously shown to be the principal mediators of resistance against Toxoplasma in mice was completely ablated by the anti-IFN-γ mAb. These results suggest that IFN-γ is the major mediator of the resistance against Toxoplasma infection in mice which is conferred by immune T cells.

Original languageEnglish
Pages (from-to)1954-1956
Number of pages3
JournalJournal of Immunology
Volume144
Issue number5
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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