The effect of cigarette smoking on functional recovery following peripheral nerve ischemia/reperfusion injury

Brian Rinker, Betsy F. Fink, Neil G. Barry, Joshua A. Fife, Maria E. Milan, Ashley R. Stoker, Peter T. Nelson

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

This study was designed to determine if cigarette smoking adversely affects functional recovery following ischemia/reperfusion (I/R) injury in peripheral nerves. Forty Wistar rats were divided evenly among four groups. Animals in groups A and B were exposed to cigarette smoke via a controlled smoking chamber for 20 minutes daily. On study day 14, all animals underwent a controlled I/R injury to one sciatic nerve. Recovery was assessed with walking track assessments, malondialdehyde (MDA) assay, and histology. Walking track results on study day 21 did not differ significantly between the smoking and nonsmoking animals. However, by study day 28, the nonsmoking animals showed a greater degree of functional recovery (SFI = -18.0 and -22.8, respectively, P = 0.03). MDA concentration in the smoking group was significantly higher than the nonsmoking group at the 28 day time point (P = 0.04). Exposure to cigarette smoke was associated with a slower functional recovery following peripheral nerve I/R injury.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalMicrosurgery
Volume31
Issue number1
DOIs
StatePublished - Jan 2011

ASJC Scopus subject areas

  • Surgery

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