The effect of cutting edge smoothness on wound healing response

F. Despa, M. Chioffe, N. Yu, C. Spiro, J. Hicks, R. C. Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A study was conducted to determine the effects of cutting edge smoothness on wound healing response. A guinea pig model was used to assess the inflammatory response and scarring in skin incisions made with an experimental blade that has an ultra-sharp, smooth cutting edge. A decrease in the density of microphages and collgen deposition area at the site of injury is indicative of decreased inflammation and improved repairing. The morphometric analysis of the wounds reveals that the wounds produced by standard surgical blades did not achieve closure. Findings demonstrate that the prevention of unneccesary disruption of tissue surrounding the incisions by using an ultrasharp and smooth blade is a key feature of the reduced inflammation and scarring.

Original languageEnglish
Pages (from-to)237-238
Number of pages2
JournalMCB Molecular and Cellular Biomechanics
Issue number4
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Biophysics
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology


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