The effect of exercise on the clearance of infused acetate in the horse

Shannon E. Pratt, Laurie M. Lawrence, Lori K. Warren, Debra M. Powell

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This study was designed to determine if exercise affected the clearance of intravenously infused acetate in the horse. Plasma acetate concentrations were measured in 4 conditioned horses during submaximal exercise and at rest following an infusion of sodium acetate (2.5 mmol/kg body weight [BW]). The effects of acetate infusion were compared with an equivolume infusion amount of 0.9% NaCl. Plasma glucose, lactate, free fatty acid, glycerol, triglyceride, and β-hydroxybutyrate concentrations were also analyzed. After infusion, plasma acetate concentrations decreased more rapidly during exercise (t 1/2: 4.5 minutes) than at rest (t1/2: 11.7 minutes; P <. 05). Although plasma acetate clearance was accelerated by exercise, there did not appear to be an increased conversion of acetate to either β-hydroxybutyrate or triglyceride, as concentrations of these variables did not increase following acetate infusion in exercising horses. Sodium acetate infusion caused a decrease in plasma free fatty acid concentrations (P <. 05) at rest and during exercise. A similar pattern occurred for glycerol concentrations (P <. 05). Glucose concentrations increased in response to acetate infusion during exercise (P <. 05). The results suggest that acetate may be useful as an energy source during submaximal exercise.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalJournal of Equine Veterinary Science
Issue number6
StatePublished - Jun 2005


  • Acetate
  • Exercise
  • Horse
  • Volatile fatty acid

ASJC Scopus subject areas

  • Equine


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