TY - JOUR
T1 - The effect of intense exercise on the cell-mediated immune response of horses
AU - Kurcz, E. V.
AU - Lawrence, L. M.
AU - Kelley, K. W.
AU - Miller, P. A.
PY - 1988
Y1 - 1988
N2 - Lymphocyte blastogenesis and serum cortisol concentrations were measured in intensely exercised horses. Four mature Quarter Horse mares were exercised to fatigue on a motorized treadmill. Blood samples were taken at rest, 15 minutes, 30 minutes, and 24 hours post-exercise. Peripheral blood mononucleocytes were isolated and cultured with 2 T cell mitogens, concanavalin A (Con A), and phytohemagglutinin (PHA) to induce proliferation of responsive T cell lymphocytes. In addition, serum cortisol concentrations were measured via a radioimmunoassay. The results reveal a significant suppression of the blastogenic response to Con A (P<.03) and PHA (P<.07) at 30 minutes after exercise. Serum cortisol concentrations were significantly increased (P<.05) at 30 minutes post-exercise. These findings suggest that severe, intense exercise may result in a suppression of the cell-mediated immunity and one possible route is through elevated glucocorticoid levels in the blood.
AB - Lymphocyte blastogenesis and serum cortisol concentrations were measured in intensely exercised horses. Four mature Quarter Horse mares were exercised to fatigue on a motorized treadmill. Blood samples were taken at rest, 15 minutes, 30 minutes, and 24 hours post-exercise. Peripheral blood mononucleocytes were isolated and cultured with 2 T cell mitogens, concanavalin A (Con A), and phytohemagglutinin (PHA) to induce proliferation of responsive T cell lymphocytes. In addition, serum cortisol concentrations were measured via a radioimmunoassay. The results reveal a significant suppression of the blastogenic response to Con A (P<.03) and PHA (P<.07) at 30 minutes after exercise. Serum cortisol concentrations were significantly increased (P<.05) at 30 minutes post-exercise. These findings suggest that severe, intense exercise may result in a suppression of the cell-mediated immunity and one possible route is through elevated glucocorticoid levels in the blood.
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U2 - 10.1016/S0737-0806(88)80015-7
DO - 10.1016/S0737-0806(88)80015-7
M3 - Article
AN - SCOPUS:0001538730
SN - 0737-0806
VL - 8
SP - 237
EP - 239
JO - Journal of Equine Veterinary Science
JF - Journal of Equine Veterinary Science
IS - 3
ER -