Abstract
Lymphocyte blastogenesis and serum cortisol concentrations were measured in intensely exercised horses. Four mature Quarter Horse mares were exercised to fatigue on a motorized treadmill. Blood samples were taken at rest, 15 minutes, 30 minutes, and 24 hours post-exercise. Peripheral blood mononucleocytes were isolated and cultured with 2 T cell mitogens, concanavalin A (Con A), and phytohemagglutinin (PHA) to induce proliferation of responsive T cell lymphocytes. In addition, serum cortisol concentrations were measured via a radioimmunoassay. The results reveal a significant suppression of the blastogenic response to Con A (P<.03) and PHA (P<.07) at 30 minutes after exercise. Serum cortisol concentrations were significantly increased (P<.05) at 30 minutes post-exercise. These findings suggest that severe, intense exercise may result in a suppression of the cell-mediated immunity and one possible route is through elevated glucocorticoid levels in the blood.
| Original language | English |
|---|---|
| Pages (from-to) | 237-239 |
| Number of pages | 3 |
| Journal | Journal of Equine Veterinary Science |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1988 |
ASJC Scopus subject areas
- Equine
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