TY - JOUR
T1 - The effect of low-density lipoprotein apheresis on plasma thrombomodulating factors
AU - Hatanaka, K.
AU - Uchida, K.
AU - Sakai, H.
AU - Kurata, M.
AU - Li, X.
AU - Yamamoto, A.
PY - 1992
Y1 - 1992
N2 - The authors have investigated the effects of double-membrane filtration with hollow fiber membranes made of different artificial materials and low- density lipoprotein (LDL)-adsorbant dextran sulfate cellulose (DS) columns on coagulation-related proteins and complement components to evaluate their hemocompatibility. All membrane filters showed similar sieving effects, which depended upon the molecular weights of the proteins. In the double-membrane filtration system, free protein S, protein C, antithrombin III, and α1- antitrypsin were returned to the intracorporeal circulation, whereas α2- macroglobulin and fibrinogen were almost completely removed from the circulation; C4b-binding protein (C4BP)-protein S complexes were also trapped by the second membrane, and in some instances were even blocked by the first membrane, if it was made of material that activated the classic pathway of the complement system. The DS column adsorbed C4BP-protein S complex, but free protein S was almost completely recovered in the eluate.
AB - The authors have investigated the effects of double-membrane filtration with hollow fiber membranes made of different artificial materials and low- density lipoprotein (LDL)-adsorbant dextran sulfate cellulose (DS) columns on coagulation-related proteins and complement components to evaluate their hemocompatibility. All membrane filters showed similar sieving effects, which depended upon the molecular weights of the proteins. In the double-membrane filtration system, free protein S, protein C, antithrombin III, and α1- antitrypsin were returned to the intracorporeal circulation, whereas α2- macroglobulin and fibrinogen were almost completely removed from the circulation; C4b-binding protein (C4BP)-protein S complexes were also trapped by the second membrane, and in some instances were even blocked by the first membrane, if it was made of material that activated the classic pathway of the complement system. The DS column adsorbed C4BP-protein S complex, but free protein S was almost completely recovered in the eluate.
UR - https://www.scopus.com/pages/publications/0026590211
UR - https://www.scopus.com/inward/citedby.url?scp=0026590211&partnerID=8YFLogxK
U2 - 10.1097/00002480-199238020-00007
DO - 10.1097/00002480-199238020-00007
M3 - Article
C2 - 1384816
AN - SCOPUS:0026590211
SN - 1058-2916
VL - 38
SP - 102
EP - 107
JO - ASAIO Journal
JF - ASAIO Journal
IS - 2
ER -