The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid

Kelly K. Hill; Scott A. West; Nosa N. Ekhator; Ann B. Bruce; Matthew D. Wortman; Dewleen G. Baker; Thomas D. Geracioti

doi:10.1016/S0304-3940(99)00778-8

The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid

Kelly K. Hill, Scott A. West, Nosa N. Ekhator, Ann B. Bruce, Matthew D. Wortman, Dewleen G. Baker, Thomas D. Geracioti

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In order to examine concentrations of cerebrospinal fluid (CSF) neurochemicals, the technique of lumbar puncture is typically used. However, the effect of the intrinsic stress of undergoing a lumbar puncture on CSF monoamine concentrations in humans has not yet been established. We used lumbar puncture followed 3 h later by continuous CSF sampling to examine the effect of lumbar puncture on levels of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Additionally, we examined the effect of lumbar puncture on the CSF HVA to 5-HIAA ratio. Immediately post lumbar puncture, CSF concentrations of HVA and 5-HIAA were, respectively, only 51 and 54% of the mean levels detected hours later. However, the HVA to 5-HIAA ratio remained stable during lumbar puncture. While HVA and 5-HIAA levels in CSF obtained via lumbar puncture reflect highly variable responses to the stress of the procedure, the ratio of these metabolites is unaffected. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Neuroscience Letters
Volume	276
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(99)00778-8
State	Published - Nov 26 1999

Bibliographical note

Funding Information:
This work was supported by Research Advisory Group and Merit Review grants from the Department of Veterans Affairs and grant No. 1K12MH009991 from the National Institute of Mental Health.

Keywords

5-Hydroxyindoleacetic acid
Cerebrospinal fluid
Dopamine
Homovanillic acid
Lumbar puncture
Post-traumatic stress disorder
Serotonin

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/S0304-3940(99)00778-8

Cite this

@article{ffe5057a4b894065afecb946d3f3a49e,

title = "The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid",

abstract = "In order to examine concentrations of cerebrospinal fluid (CSF) neurochemicals, the technique of lumbar puncture is typically used. However, the effect of the intrinsic stress of undergoing a lumbar puncture on CSF monoamine concentrations in humans has not yet been established. We used lumbar puncture followed 3 h later by continuous CSF sampling to examine the effect of lumbar puncture on levels of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Additionally, we examined the effect of lumbar puncture on the CSF HVA to 5-HIAA ratio. Immediately post lumbar puncture, CSF concentrations of HVA and 5-HIAA were, respectively, only 51 and 54% of the mean levels detected hours later. However, the HVA to 5-HIAA ratio remained stable during lumbar puncture. While HVA and 5-HIAA levels in CSF obtained via lumbar puncture reflect highly variable responses to the stress of the procedure, the ratio of these metabolites is unaffected. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "5-Hydroxyindoleacetic acid, Cerebrospinal fluid, Dopamine, Homovanillic acid, Lumbar puncture, Post-traumatic stress disorder, Serotonin",

author = "Hill, {Kelly K.} and West, {Scott A.} and Ekhator, {Nosa N.} and Bruce, {Ann B.} and Wortman, {Matthew D.} and Baker, {Dewleen G.} and Geracioti, {Thomas D.}",

note = "Funding Information: This work was supported by Research Advisory Group and Merit Review grants from the Department of Veterans Affairs and grant No. 1K12MH009991 from the National Institute of Mental Health.",

year = "1999",

month = nov,

day = "26",

doi = "10.1016/S0304-3940(99)00778-8",

language = "English",

volume = "276",

pages = "25--28",

number = "1",

}

TY - JOUR

T1 - The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid

AU - Hill, Kelly K.

AU - West, Scott A.

AU - Ekhator, Nosa N.

AU - Bruce, Ann B.

AU - Wortman, Matthew D.

AU - Baker, Dewleen G.

AU - Geracioti, Thomas D.

N1 - Funding Information: This work was supported by Research Advisory Group and Merit Review grants from the Department of Veterans Affairs and grant No. 1K12MH009991 from the National Institute of Mental Health.

PY - 1999/11/26

Y1 - 1999/11/26

N2 - In order to examine concentrations of cerebrospinal fluid (CSF) neurochemicals, the technique of lumbar puncture is typically used. However, the effect of the intrinsic stress of undergoing a lumbar puncture on CSF monoamine concentrations in humans has not yet been established. We used lumbar puncture followed 3 h later by continuous CSF sampling to examine the effect of lumbar puncture on levels of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Additionally, we examined the effect of lumbar puncture on the CSF HVA to 5-HIAA ratio. Immediately post lumbar puncture, CSF concentrations of HVA and 5-HIAA were, respectively, only 51 and 54% of the mean levels detected hours later. However, the HVA to 5-HIAA ratio remained stable during lumbar puncture. While HVA and 5-HIAA levels in CSF obtained via lumbar puncture reflect highly variable responses to the stress of the procedure, the ratio of these metabolites is unaffected. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - In order to examine concentrations of cerebrospinal fluid (CSF) neurochemicals, the technique of lumbar puncture is typically used. However, the effect of the intrinsic stress of undergoing a lumbar puncture on CSF monoamine concentrations in humans has not yet been established. We used lumbar puncture followed 3 h later by continuous CSF sampling to examine the effect of lumbar puncture on levels of the dopamine and serotonin metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Additionally, we examined the effect of lumbar puncture on the CSF HVA to 5-HIAA ratio. Immediately post lumbar puncture, CSF concentrations of HVA and 5-HIAA were, respectively, only 51 and 54% of the mean levels detected hours later. However, the HVA to 5-HIAA ratio remained stable during lumbar puncture. While HVA and 5-HIAA levels in CSF obtained via lumbar puncture reflect highly variable responses to the stress of the procedure, the ratio of these metabolites is unaffected. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - 5-Hydroxyindoleacetic acid

KW - Cerebrospinal fluid

KW - Dopamine

KW - Homovanillic acid

KW - Lumbar puncture

KW - Post-traumatic stress disorder

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0032696940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032696940&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(99)00778-8

DO - 10.1016/S0304-3940(99)00778-8

M3 - Article

C2 - 10586966

AN - SCOPUS:0032696940

SN - 0304-3940

VL - 276

SP - 25

EP - 28

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this