The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments

Nicholas G. Schott, Ramkumar T. Annamalai, Benjamin A. Juliar, Jan P. Stegemann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Statement of Purpose: The inability to create functional vasculature has hampered the clinical application of bone tissue engineering strategies. Cell-based therapies using mesenchymal stromal cells (MSC) have shown potential in enhancing bone formation and neo-vascularization1. However, it is challenging to harness these attributes due to inherent difficulties in directing and maintaining MSC phenotypes with the potential to promote vasculogenesis and osteogenesis. Hence there is a need for improved tissue engineering strategies that utilize their dual potential. In this study we analyzed the temporal plasticity of MSC under osteogenic (OST) and vasculogenic (VAS) stimulation with the long-term goal of developing a multiphasic cell-based therapy for bone regeneration.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Pages131
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

Bibliographical note

Publisher Copyright:
© 2019 Omnipress - All rights reserved.

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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