The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments

Nicholas G. Schott; Ramkumar T. Annamalai; Benjamin A. Juliar; Jan P. Stegemann

The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments

Nicholas G. Schott, Ramkumar T. Annamalai, Benjamin A. Juliar, Jan P. Stegemann

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Statement of Purpose: The inability to create functional vasculature has hampered the clinical application of bone tissue engineering strategies. Cell-based therapies using mesenchymal stromal cells (MSC) have shown potential in enhancing bone formation and neo-vascularization¹. However, it is challenging to harness these attributes due to inherent difficulties in directing and maintaining MSC phenotypes with the potential to promote vasculogenesis and osteogenesis. Hence there is a need for improved tissue engineering strategies that utilize their dual potential. In this study we analyzed the temporal plasticity of MSC under osteogenic (OST) and vasculogenic (VAS) stimulation with the long-term goal of developing a multiphasic cell-based therapy for bone regeneration.

Original language	English
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Pages	131
Number of pages	1
ISBN (Electronic)	9781510883901
State	Published - 2019
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40
ISSN (Print)	1526-7547

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/Territory	United States
City	Seattle
Period	4/3/19 → 4/6/19

ASJC Scopus subject areas

Biochemistry
Biophysics
Biotechnology
Biomaterials
Materials Chemistry

Cite this

Schott, N. G., Annamalai, R. T., Juliar, B. A., & Stegemann, J. P. (2019). The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 131). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Schott, Nicholas G. ; Annamalai, Ramkumar T. ; Juliar, Benjamin A. et al. / The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. 2019. pp. 131 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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title = "The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments",

abstract = "Statement of Purpose: The inability to create functional vasculature has hampered the clinical application of bone tissue engineering strategies. Cell-based therapies using mesenchymal stromal cells (MSC) have shown potential in enhancing bone formation and neo-vascularization1. However, it is challenging to harness these attributes due to inherent difficulties in directing and maintaining MSC phenotypes with the potential to promote vasculogenesis and osteogenesis. Hence there is a need for improved tissue engineering strategies that utilize their dual potential. In this study we analyzed the temporal plasticity of MSC under osteogenic (OST) and vasculogenic (VAS) stimulation with the long-term goal of developing a multiphasic cell-based therapy for bone regeneration.",

author = "Schott, {Nicholas G.} and Annamalai, {Ramkumar T.} and Juliar, {Benjamin A.} and Stegemann, {Jan P.}",

year = "2019",

language = "English",

series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",

pages = "131",

booktitle = "Society for Biomaterials Annual Meeting and Exposition 2019",

note = "42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence ; Conference date: 03-04-2019 Through 06-04-2019",

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Schott, NG, Annamalai, RT, Juliar, BA & Stegemann, JP 2019, The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, pp. 131, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments. / Schott, Nicholas G.; Annamalai, Ramkumar T.; Juliar, Benjamin A. et al.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. 2019. p. 131 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Statement of Purpose: The inability to create functional vasculature has hampered the clinical application of bone tissue engineering strategies. Cell-based therapies using mesenchymal stromal cells (MSC) have shown potential in enhancing bone formation and neo-vascularization1. However, it is challenging to harness these attributes due to inherent difficulties in directing and maintaining MSC phenotypes with the potential to promote vasculogenesis and osteogenesis. Hence there is a need for improved tissue engineering strategies that utilize their dual potential. In this study we analyzed the temporal plasticity of MSC under osteogenic (OST) and vasculogenic (VAS) stimulation with the long-term goal of developing a multiphasic cell-based therapy for bone regeneration.

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Schott NG, Annamalai RT, Juliar BA, Stegemann JP. The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. 2019. p. 131. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

The effect of MSC phenotype on osteogenesis and vasculogenesis in engineered multiphase microenvironments

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