TY - JOUR
T1 - The effect of the fiber components cellulose and lignin on experimental colon neoplasia
AU - Sloan, David A.
AU - Fleiszer, David M.
AU - Richards, Geoffrey K.
AU - Murray, David
AU - Brown, Rea A.
PY - 1993/2
Y1 - 1993/2
N2 - Sixty Sprague‐Dawley rats were pair‐fed one of three nutritionally identical diets. One diet contained “low‐fiber” (3.8% crude fiber); the others contained “high fiber” (28.7% crude fiber) composed of either cellulose or lignin. Although both “high fiber” diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2‐dimethylhydrazine (DMH)‐induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol. © 1993 Wiley‐Liss, Inc.
AB - Sixty Sprague‐Dawley rats were pair‐fed one of three nutritionally identical diets. One diet contained “low‐fiber” (3.8% crude fiber); the others contained “high fiber” (28.7% crude fiber) composed of either cellulose or lignin. Although both “high fiber” diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2‐dimethylhydrazine (DMH)‐induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol. © 1993 Wiley‐Liss, Inc.
KW - dietary fiber
KW - gut bacteria
KW - rats
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U2 - 10.1002/jso.2930520204
DO - 10.1002/jso.2930520204
M3 - Article
C2 - 8385723
AN - SCOPUS:0027516130
SN - 0022-4790
VL - 52
SP - 77
EP - 82
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -