The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities

Bethany Jablonski Horton; Thomas J. Luben; Amy H. Herring; David A. Savitz; Philip C. Singer; Howard S. Weinberg; Katherine E. Hartmann

doi:10.1097/JOM.0b013e31822b8334

The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities

Bethany Jablonski Horton, Thomas J. Luben, Amy H. Herring, David A. Savitz, Philip C. Singer, Howard S. Weinberg, Katherine E. Hartmann

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Objective: To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation). Methods: We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression. Results: We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB. Conclusions: Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.

Original language	English
Pages (from-to)	1172-1178
Number of pages	7
Journal	Journal of Occupational and Environmental Medicine
Volume	53
Issue number	10
DOIs	https://doi.org/10.1097/JOM.0b013e31822b8334
State	Published - Oct 2011

Funding

This study was funded jointly by the AWWA Research Foundation (AwwaRF: Project 2579) and the US Environmental Protection Agency (USEPA) under Cooperative Agreement Nos. CR825625-01, CR827268-01, and CR828216-01, the Center for Environmental Health and Susceptibility (CEHS) at the University of North Carolina at Chapel Hill (P30E510126), US EPA STAR award RD-83184301-0, and NIH/NIEHS T32ES007018.

Funders	Funder number
UNC-Chapel Hill Center for Environmental Health and Susceptibility
National Institutes of Health (NIH)
National Institutes of Health/National Institute of Environmental Health Sciences	T32ES007018
U.S. Environmental Protection Agency	RD-83184301-0, CR827268-01, CR828216-01, CR825625-01
American Water Works Association Research Foundation	2579
University of North Carolina, Chapel Hill	P30E510126

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JOM.0b013e31822b8334

Cite this

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title = "The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities",

abstract = "Objective: To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation). Methods: We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression. Results: We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB. Conclusions: Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.",

author = "Horton, \{Bethany Jablonski\} and Luben, \{Thomas J.\} and Herring, \{Amy H.\} and Savitz, \{David A.\} and Singer, \{Philip C.\} and Weinberg, \{Howard S.\} and Hartmann, \{Katherine E.\}",

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AU - Horton, Bethany Jablonski

AU - Luben, Thomas J.

AU - Herring, Amy H.

AU - Savitz, David A.

AU - Singer, Philip C.

AU - Weinberg, Howard S.

AU - Hartmann, Katherine E.

PY - 2011/10

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N2 - Objective: To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation). Methods: We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression. Results: We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB. Conclusions: Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.

AB - Objective: To determine if exposure to disinfection by-products (DBPs) during gestation increases the risk of adverse birth outcomes, specifically term small for gestational age (SGA) birth, preterm birth (PTB), and very PTB (<32 weeks' gestation). Methods: We used weekly measurements total trihalomethanes (TTHMs), five haloacetic acids (HAA5), and total organic halides (TOX) collected from two distribution systems to evaluate the associations between DBP concentrations and term SGA, PTB, and very PTB using logistic regression. Results: We found no associations between DBPs and term-SGA. In the site with higher concentrations of bromine-containing DBPs, we found an association between TOX and PTB; this association was larger, though less precise, for very PTB. Conclusions: Our results do not support an association between TTHMs or HAA5 and the birth outcomes investigated, but an association was found between increased TOX and PTB.

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The effect of water disinfection by-products on pregnancy outcomes in two southeastern US communities

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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