The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper; Micaiah McNabb; Jeremy Nadolski

doi:10.1016/j.heliyon.2019.e01430

The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper, Micaiah McNabb, Jeremy Nadolski

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

Original language	English
Article number	e01430
Journal	Heliyon
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.heliyon.2019.e01430
State	Published - Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors

Keywords

Immunology
Neuroscience
Physiology
Zoology

ASJC Scopus subject areas

General

Access to Document

10.1016/j.heliyon.2019.e01430

Cite this

@article{115d78f11c484ad1ba193b7d7acd2539,

title = "The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction",

abstract = "The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.",

keywords = "Immunology, Neuroscience, Physiology, Zoology",

author = "Cooper, {Robin L.} and Micaiah McNabb and Jeremy Nadolski",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = mar,

doi = "10.1016/j.heliyon.2019.e01430",

language = "English",

volume = "5",

number = "3",

}

TY - JOUR

T1 - The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

AU - Cooper, Robin L.

AU - McNabb, Micaiah

AU - Nadolski, Jeremy

PY - 2019/3

Y1 - 2019/3

N2 - The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

AB - The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

KW - Immunology

KW - Neuroscience

KW - Physiology

KW - Zoology

UR - http://www.scopus.com/inward/record.url?scp=85063400703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063400703&partnerID=8YFLogxK

U2 - 10.1016/j.heliyon.2019.e01430

DO - 10.1016/j.heliyon.2019.e01430

M3 - Article

AN - SCOPUS:85063400703

SN - 2405-8440

VL - 5

JO - Heliyon

JF - Heliyon

IS - 3

M1 - e01430

ER -

The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this