The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper, Micaiah McNabb, Jeremy Nadolski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

Original languageEnglish
Article numbere01430
JournalHeliyon
Volume5
Issue number3
DOIs
StatePublished - Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors

Keywords

  • Immunology
  • Neuroscience
  • Physiology
  • Zoology

ASJC Scopus subject areas

  • General

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