The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper; Micaiah McNabb; Jeremy Nadolski

doi:10.1016/j.heliyon.2019.e01430

The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Robin L. Cooper, Micaiah McNabb, Jeremy Nadolski

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

Original language	English
Article number	e01430
Journal	Heliyon
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.heliyon.2019.e01430
State	Published - Mar 2019

Bibliographical note

Funding Information:
This work was supported by personal funds (R.L.C.) and a “Sustaining Excellence-2014” competition grant from the Howard Hughes Medical Institute (Grant #52008116 ) awarded to the University of Kentucky (VM Cassone, PI). The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.

Publisher Copyright:
© 2019 The Authors

Keywords

Immunology
Neuroscience
Physiology
Zoology

ASJC Scopus subject areas

General

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10.1016/j.heliyon.2019.e01430

Cite this

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abstract = "The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.",

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AB - The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.

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The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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