Abstract
The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response.
| Original language | English |
|---|---|
| Article number | e01430 |
| Journal | Heliyon |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2019 |
Bibliographical note
Publisher Copyright:© 2019 The Authors
Funding
This work was supported by personal funds (R.L.C.) and a “Sustaining Excellence-2014” competition grant from the Howard Hughes Medical Institute (Grant #52008116 ) awarded to the University of Kentucky (VM Cassone, PI). The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal.
| Funders | Funder number |
|---|---|
| Howard Hughes Medical Institute | 52008116 |
| University of Kentucky |
Keywords
- Immunology
- Neuroscience
- Physiology
- Zoology
ASJC Scopus subject areas
- General
Fingerprint
Dive into the research topics of 'The effects of bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver