The effects of cholecystokinin (CCK-8) on dopamine-containing nerve terminals in the caudate nucleus and nucleus accumbens of the anesthetized rat: an in vivo electrochemical study

Greg A. Gerhardt, Marilyn Friedemann, Mark S. Brodie, Thomas W. Vickroy, Alain P. Gratton, Barry J. Hoffer, Greg M. Rose

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The action of cholecystokinin (CCK) on presynaptic function of dopaminergic nerve terminals has been the subject of much debate in the literature. In efforts to resolve some of the reported ambiguities, high speed in vivo electrochemical recordings were carried out in the caudate nucleus and nucleus accumbens of the urethane anesthetized rat, to determine effects of locally applied sulfated (CCK-8S) and unsulfated (CCK-8US) CCK octapeptide. Locally-applied CCK-8S and CCK-8US caused no increase in the baseline electrochemical signals recorded from either brain region. However, locally applied CCK-8S potentiated the potassium-evoked overflow of dopamine (DA) into the extracellular space in both the caudate and nucleus accumbens. In contrast, pressure ejection of CCK-8US produced no significant effects on the potassium-evoked overflow of DA in either structure. These data support a facilitatory effect of CCK-8S on potassium-evoked overflow from DA-containing nerve terminals in the urethane anesthetized rat that is likely mediated through a peripheral type CCK receptor.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalBrain Research
Volume499
Issue number1
DOIs
StatePublished - Oct 9 1989

Bibliographical note

Funding Information:
Supported by USPHS Grants AG06434, AG00441, AG04418, NS09199, and the Veterans AdministratioRne searchS ervice.W e would like to thank Dr. Alex Nadzanf or help in the planningo f these experimentsa nd for his expert technical support.

Keywords

  • Caudate nucleus
  • Cholecystokinin
  • Dopamine
  • In vivo electrochemistry
  • Nucleus accumbens
  • Potassium

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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