The effects of dietary chromium(III) picolinate on growth performance, vital signs, and blood measurements of pigs during immune stress

Beob G. Kim; Merlin D. Lindemann; Gary L. Cromwell

doi:10.1007/s12011-009-8503-x

The effects of dietary chromium(III) picolinate on growth performance, vital signs, and blood measurements of pigs during immune stress

Beob G. Kim, Merlin D. Lindemann, Gary L. Cromwell

Animal and Food Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This experiment used 24 pigs (26.0 kg) to investigate the effects of dietary chromium (Cr) on pigs challenged with lipopolysaccharide (LPS). Following 35 days of diet exposure, the immune stress treatments were: (1) phosphate-buffered saline (PBS) injection and no Cr, (2) LPS injection and no Cr, (3) LPS injection and Cr 1,000 ppb, and (4) LPS injection and Cr 2,000 ppb. At 0 h, PBS or LPS was injected intraperitoneally in each pig. During the first 12 h post-injection, pigs challenged with LPS lost 951 g, while the PBS group gained 170 g (p<0.001). Compared with the PBS group, LPS-challenged pigs consumed less feed (p<0.01) during the first 24 h. The LPS group had higher rectal temperature at 2 and 4 h and higher respiratory rate at 1.3 and 8.5 h than the PBS group (p<0.05). Plasma collected at 3 h had higher cortisol (p<0.001) and lower glucose (p<0.05) concentrations in the LPS group than the PBS group. However, supplemental Cr did not affect the response variables. Overall, the LPS challenge affects growth performance, vital signs, and plasma variables, but dietary Cr is unable to moderate stress-related effects associated with an LPS challenge.

Original language	English
Pages (from-to)	200-210
Number of pages	11
Journal	Biological Trace Element Research
Volume	135
Issue number	1-3
DOIs	https://doi.org/10.1007/s12011-009-8503-x
State	Published - Jun 2010

Bibliographical note

Funding Information:
Acknowledgments The present manuscript is based on research supported in part by the Kentucky Agricultural Experiment Station and is published by the Kentucky Agric. Exp. Stn. as paper no. 08-07-023. The authors express appreciation to Susan Hayes and Aitor Balfagon for technical assistance in data collection and to David Higginbotham for help in diet preparation. The authors also thank APC, Inc., Ankeny, IA and Akey, Inc., Lewisburg, OH for ingredients used in the experiment. During this research, B. G. Kim was a recipient of the Kentucky Opportunity Fellowship.

Funding

Acknowledgments The present manuscript is based on research supported in part by the Kentucky Agricultural Experiment Station and is published by the Kentucky Agric. Exp. Stn. as paper no. 08-07-023. The authors express appreciation to Susan Hayes and Aitor Balfagon for technical assistance in data collection and to David Higginbotham for help in diet preparation. The authors also thank APC, Inc., Ankeny, IA and Akey, Inc., Lewisburg, OH for ingredients used in the experiment. During this research, B. G. Kim was a recipient of the Kentucky Opportunity Fellowship.

Funders	Funder number
Kentucky Agric
Kentucky Agricultural Experiment Station

Keywords

Chromium
Cortisol
Glucose
Growth performance
Immune stress
Lipopolysaccharide
Pigs
Rectal temperature
Respiratory rate

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry
Biochemistry, medical
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12011-009-8503-x

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@article{3e74e6bcef9d46638e9d41e1a1a5c575,

title = "The effects of dietary chromium(III) picolinate on growth performance, vital signs, and blood measurements of pigs during immune stress",

abstract = "This experiment used 24 pigs (26.0 kg) to investigate the effects of dietary chromium (Cr) on pigs challenged with lipopolysaccharide (LPS). Following 35 days of diet exposure, the immune stress treatments were: (1) phosphate-buffered saline (PBS) injection and no Cr, (2) LPS injection and no Cr, (3) LPS injection and Cr 1,000 ppb, and (4) LPS injection and Cr 2,000 ppb. At 0 h, PBS or LPS was injected intraperitoneally in each pig. During the first 12 h post-injection, pigs challenged with LPS lost 951 g, while the PBS group gained 170 g (p<0.001). Compared with the PBS group, LPS-challenged pigs consumed less feed (p<0.01) during the first 24 h. The LPS group had higher rectal temperature at 2 and 4 h and higher respiratory rate at 1.3 and 8.5 h than the PBS group (p<0.05). Plasma collected at 3 h had higher cortisol (p<0.001) and lower glucose (p<0.05) concentrations in the LPS group than the PBS group. However, supplemental Cr did not affect the response variables. Overall, the LPS challenge affects growth performance, vital signs, and plasma variables, but dietary Cr is unable to moderate stress-related effects associated with an LPS challenge.",

keywords = "Chromium, Cortisol, Glucose, Growth performance, Immune stress, Lipopolysaccharide, Pigs, Rectal temperature, Respiratory rate",

author = "Kim, {Beob G.} and Lindemann, {Merlin D.} and Cromwell, {Gary L.}",

note = "Funding Information: Acknowledgments The present manuscript is based on research supported in part by the Kentucky Agricultural Experiment Station and is published by the Kentucky Agric. Exp. Stn. as paper no. 08-07-023. The authors express appreciation to Susan Hayes and Aitor Balfagon for technical assistance in data collection and to David Higginbotham for help in diet preparation. The authors also thank APC, Inc., Ankeny, IA and Akey, Inc., Lewisburg, OH for ingredients used in the experiment. During this research, B. G. Kim was a recipient of the Kentucky Opportunity Fellowship.",

year = "2010",

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doi = "10.1007/s12011-009-8503-x",

language = "English",

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AU - Kim, Beob G.

AU - Lindemann, Merlin D.

AU - Cromwell, Gary L.

N1 - Funding Information: Acknowledgments The present manuscript is based on research supported in part by the Kentucky Agricultural Experiment Station and is published by the Kentucky Agric. Exp. Stn. as paper no. 08-07-023. The authors express appreciation to Susan Hayes and Aitor Balfagon for technical assistance in data collection and to David Higginbotham for help in diet preparation. The authors also thank APC, Inc., Ankeny, IA and Akey, Inc., Lewisburg, OH for ingredients used in the experiment. During this research, B. G. Kim was a recipient of the Kentucky Opportunity Fellowship.

PY - 2010/6

Y1 - 2010/6

N2 - This experiment used 24 pigs (26.0 kg) to investigate the effects of dietary chromium (Cr) on pigs challenged with lipopolysaccharide (LPS). Following 35 days of diet exposure, the immune stress treatments were: (1) phosphate-buffered saline (PBS) injection and no Cr, (2) LPS injection and no Cr, (3) LPS injection and Cr 1,000 ppb, and (4) LPS injection and Cr 2,000 ppb. At 0 h, PBS or LPS was injected intraperitoneally in each pig. During the first 12 h post-injection, pigs challenged with LPS lost 951 g, while the PBS group gained 170 g (p<0.001). Compared with the PBS group, LPS-challenged pigs consumed less feed (p<0.01) during the first 24 h. The LPS group had higher rectal temperature at 2 and 4 h and higher respiratory rate at 1.3 and 8.5 h than the PBS group (p<0.05). Plasma collected at 3 h had higher cortisol (p<0.001) and lower glucose (p<0.05) concentrations in the LPS group than the PBS group. However, supplemental Cr did not affect the response variables. Overall, the LPS challenge affects growth performance, vital signs, and plasma variables, but dietary Cr is unable to moderate stress-related effects associated with an LPS challenge.

AB - This experiment used 24 pigs (26.0 kg) to investigate the effects of dietary chromium (Cr) on pigs challenged with lipopolysaccharide (LPS). Following 35 days of diet exposure, the immune stress treatments were: (1) phosphate-buffered saline (PBS) injection and no Cr, (2) LPS injection and no Cr, (3) LPS injection and Cr 1,000 ppb, and (4) LPS injection and Cr 2,000 ppb. At 0 h, PBS or LPS was injected intraperitoneally in each pig. During the first 12 h post-injection, pigs challenged with LPS lost 951 g, while the PBS group gained 170 g (p<0.001). Compared with the PBS group, LPS-challenged pigs consumed less feed (p<0.01) during the first 24 h. The LPS group had higher rectal temperature at 2 and 4 h and higher respiratory rate at 1.3 and 8.5 h than the PBS group (p<0.05). Plasma collected at 3 h had higher cortisol (p<0.001) and lower glucose (p<0.05) concentrations in the LPS group than the PBS group. However, supplemental Cr did not affect the response variables. Overall, the LPS challenge affects growth performance, vital signs, and plasma variables, but dietary Cr is unable to moderate stress-related effects associated with an LPS challenge.

KW - Chromium

KW - Cortisol

KW - Glucose

KW - Growth performance

KW - Immune stress

KW - Lipopolysaccharide

KW - Pigs

KW - Rectal temperature

KW - Respiratory rate

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SN - 0163-4984

VL - 135

SP - 200

EP - 210

JO - Biological Trace Element Research

JF - Biological Trace Element Research

IS - 1-3

ER -

The effects of dietary chromium(III) picolinate on growth performance, vital signs, and blood measurements of pigs during immune stress

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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