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Abstract
Intra-articular corticosteroids are a popular treatment choice for joint-associated pain and inflammation in horses despite recent work on the metabolic effects of these drugs. The goal of this project was to compare metabolic effects between intra-articular (IA) triamcinolone acetonide (TA) and an autologous protein solution (APS). Five mixed-breed geldings (4-9 years) were utilized for this project. Three identical and consecutive 28-day treatment blocks were used, with metacarpophalangeal IA treatments consisting of equal volumes of saline, a commercially available APS, or 9 mg of TA. Regular plasma and serum samples were collected for ACTH, cortisol, glucose, insulin, and thyroid hormone analysis, in addition to thyrotropin-releasing hormone (TRH) and oral sugar tests (OSTs). Significant treatment effects of IA TA were present at 48 h post-injection in both the TRH and the OST. There was also significant suppression by IA TA of baseline ACTH and cortisol between 2 h and 96 h post-treatment, hyperglycemia between 12 h and 48 h, and hyperinsulinemia at 32 h post-treatment. There were no treatment effects with respect to any measured thyroid hormones, nor were there any significant treatment effects of APS noted. Results suggest at least 2 days and up to 7 days should elapse between a single 9 mg IA TA treatment and OST and/or TRH testing. This study found that TA exhibits significant effects on ACTH, cortisol, glucose, and insulin, while the APS does not.
Original language | English |
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Journal | Animals |
Volume | 14 |
Issue number | 15 |
DOIs | |
State | Published - Aug 2 2024 |
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Dive into the research topics of 'The Effects of Intra-Articular Triamcinolone and Autologous Protein Solution on Metabolic Parameters in Horses'. Together they form a unique fingerprint.Projects
- 1 Finished
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The Effect of Intra-Articular Triamcinolone and Pro-Stride APS on Metabolic Parameters in Horses
Page, A. (PI), Adam, E. (CoI) & Adams, A. (CoI)
2/1/23 → 3/31/24
Project: Research project