TY - JOUR
T1 - The effects of perinatal oxycodone exposure on behavioral outcome in a rodent model
AU - Sithisarn, Thitinart
AU - Legan, Sandra J.
AU - Westgate, Philip M.
AU - Wilson, Melinda
AU - Wellmann, Kristen
AU - Bada, Henrietta S.
AU - Barron, Susan
PY - 2017/8/25
Y1 - 2017/8/25
N2 - Opiate addiction is now a major public health problem. Perinatal insults and exposure to opiates such as morphine in utero are well known to affect development of the hypothalamic-pituitary-adrenal axis of the offspring adversely and are associated with a higher risk of developing neurobehavioral problems. Oxycodone is now one of the most frequently abused pain killers during pregnancy; however, limited data are available regarding whether and how perinatal oxycodone exposure (POE) alters neurobehavioral outcomes of the offspring. We demonstrated that exposure to 0.5 mg/kg/day oxycodone in utero was associated with hyperactivity in adult rats in an open field. No significant effects of POE were detected on isolation-induced ultrasonic vocalizations in the early postnatal period or on learning and memory in the water maze in adult offspring. Our findings are consistent with hyperactivity problems identified in children exposed to opiates in utero. 2017 Sithisarn, Legan, Westgate, Wilson, Wellmann, Bada and Barron.
AB - Opiate addiction is now a major public health problem. Perinatal insults and exposure to opiates such as morphine in utero are well known to affect development of the hypothalamic-pituitary-adrenal axis of the offspring adversely and are associated with a higher risk of developing neurobehavioral problems. Oxycodone is now one of the most frequently abused pain killers during pregnancy; however, limited data are available regarding whether and how perinatal oxycodone exposure (POE) alters neurobehavioral outcomes of the offspring. We demonstrated that exposure to 0.5 mg/kg/day oxycodone in utero was associated with hyperactivity in adult rats in an open field. No significant effects of POE were detected on isolation-induced ultrasonic vocalizations in the early postnatal period or on learning and memory in the water maze in adult offspring. Our findings are consistent with hyperactivity problems identified in children exposed to opiates in utero. 2017 Sithisarn, Legan, Westgate, Wilson, Wellmann, Bada and Barron.
KW - Behavior
KW - Hyperactivity
KW - Learning and memory
KW - Prenatal opiate exposure
KW - Prenatal oxycodone exposure
KW - Ultrasonic vocalization
UR - http://www.scopus.com/inward/record.url?scp=85041994540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041994540&partnerID=8YFLogxK
U2 - 10.3389/fped.2017.00180
DO - 10.3389/fped.2017.00180
M3 - Article
AN - SCOPUS:85041994540
VL - 5
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 180
ER -