The effects of withaferin a on normal and malignant immune cells

Sara S. Alhakeem, Mary K. McKenna, Karine Z. Oben, Beth W. Gachuki, Sunil K. Noothi, Natarajan Muthusamy, Vivek M. Rangnekar, Ramesh C. Gupta, Subbarao Bondada

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Ashwagandha, an ayurvedic medicinal plant, has been found to be a major contributor in treating medical ailments. Ayurveda is one of the world's oldest traditional medical systems originated in India through various indigenous theories, beliefs and experiences. Often translated as science of "ayus" (life) and "ved" (knowledge), it emphasizes the use of herbs and their derivatives for prevention of disease, rejuvenation of body systems, and improving the quality of life. In this chapter, we will discuss some of the immuno-modulatory effects of withaferin A (WFA) as well as its growth-inhibitory effects on B cell lymphoma, leukemia and myelodysplastic syndrome.

Original languageEnglish
Title of host publicationScience of Ashwagandha
Subtitle of host publicationPreventive and Therapeutic Potentials
Number of pages16
ISBN (Electronic)9783319591926
StatePublished - Sep 13 2017

Bibliographical note

Publisher Copyright:
© Springer International Publishing AG 2017. All rights are reserved.


  • B cell lymphoma
  • Growth-inhibitory effects
  • Immuno-modulatory effects
  • Withaferin A
  • Withania somnifera

ASJC Scopus subject areas

  • General Medicine
  • General Social Sciences


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