The emerging landscape of circular RNA in cardiovascular diseases

Meng yuan Zhou, Jin Ming Yang, Xing dong Xiong

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Circular RNAs (circRNAs), a large novel type of endogenous transcripts, have become a new research hotspot in the field of RNA biology. CircRNAs are mainly generated from exons or introns via multiple mechanisms, and the majority of circRNAs are stable and conserved across different species. Recent studies have revealed that circRNAs can function as miRNA sponges, binding partners of proteins, regulators of transcription, or can even be translated into proteins. Growing evidence has demonstrated that circRNAs play important roles in a wide variety of biological processes such as cell proliferation, apoptosis and senescence, and may serve as potential diagnostic biomarkers or therapeutic targets for various cardiovascular diseases. Here, we review the biogenesis, properties and biological function of circRNAs, and summarize their roles in cardiovascular disorders.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalJournal of Molecular and Cellular Cardiology
Volume122
DOIs
StatePublished - Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Biomarker
  • Cardiovascular disease
  • CircRNA
  • MiRNA sponge
  • RNA binding protein

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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