The emerging role of curcumin for improving vascular dysfunction: A review

Marilyn S Campbell, Bradley S Fleenor

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Curcumin, when administered in a bioavailable form, has potential to influence vascular health of various populations, leading to decreases in cardiovascular disease risk. Clinical intervention studies with curcumin have demonstrated significant improvements in endothelial function, arterial compliance, arterial stiffness, and other measures of vascular hemodynamics in young, middle-aged, old, post-menopausal, healthy, diabetic, and obese individuals. Mechanistically, curcumin is believed to improve vascular function through its effects on inflammation, oxidative stress, nitric oxide bioavailability, and structural proteins of the artery. Current data give support for curcumin to be administered for improvements in vascular health to individuals that may or may not be at risk for cardiovascular disease. This review briefly summarizes the techniques used for the establishment of vascular health and overviews the literature investigating the role of curcumin in the improvement of vascular health.

Original languageEnglish
Pages (from-to)2790-2799
Number of pages10
JournalCritical Reviews in Food Science and Nutrition
Volume58
Issue number16
DOIs
StatePublished - 2018

Keywords

  • Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
  • Cardiovascular Diseases/drug therapy
  • Curcumin/therapeutic use
  • Hemodynamics
  • Humans
  • Phytotherapy

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