TY - JOUR
T1 - The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease
T2 - A potential target for antioxidant nanotherapeutics
AU - Gupta, Prachi
AU - Thompson, Brendan L.
AU - Wahlang, Banrida
AU - Jordan, Carolyn T.
AU - Hilt, J. Zach
AU - Hennig, Bernhard
AU - Dziubla, Thomas
N1 - Publisher Copyright:
© Controlled Release Society 2017.
PY - 2018/10/3
Y1 - 2018/10/3
N2 - Despite production having stopped in the 1970s, polychlorinated biphenyls (PCBs) represent persistent organic pollutants that continue to pose a serious human health risk. Exposure to PCBs has been linked to chronic inflammatory diseases, such as cardiovascular disease, type 2 diabetes, obesity, as well as hepatic disorders, endocrine dysfunction, neurological deficits, and many others. This is further complicated by the PCB’s strong hydrophobicity, resulting in their ability to accumulate up the food chain and to be stored in fat deposits. This means that completely avoiding exposure is not possible, thus requiring the need to develop intervention strategies that can mitigate disease risks associated with exposure to PCBs. Currently, there is excitement in the use of nutritional compounds as a way of inhibiting the inflammation associated with PCBs, yet the suboptimal delivery and pharmacology of these compounds may not be sufficient in more acute exposures. In this review, we discuss the current state of knowledge of PCB toxicity and some of the antioxidant and anti-inflammatory nanocarrier systems that may be useful as an enhanced treatment modality for reducing PCB toxicity.
AB - Despite production having stopped in the 1970s, polychlorinated biphenyls (PCBs) represent persistent organic pollutants that continue to pose a serious human health risk. Exposure to PCBs has been linked to chronic inflammatory diseases, such as cardiovascular disease, type 2 diabetes, obesity, as well as hepatic disorders, endocrine dysfunction, neurological deficits, and many others. This is further complicated by the PCB’s strong hydrophobicity, resulting in their ability to accumulate up the food chain and to be stored in fat deposits. This means that completely avoiding exposure is not possible, thus requiring the need to develop intervention strategies that can mitigate disease risks associated with exposure to PCBs. Currently, there is excitement in the use of nutritional compounds as a way of inhibiting the inflammation associated with PCBs, yet the suboptimal delivery and pharmacology of these compounds may not be sufficient in more acute exposures. In this review, we discuss the current state of knowledge of PCB toxicity and some of the antioxidant and anti-inflammatory nanocarrier systems that may be useful as an enhanced treatment modality for reducing PCB toxicity.
KW - Antioxidant
KW - Nanocarriers
KW - PCBs
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85053084783&partnerID=8YFLogxK
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U2 - 10.1007/s13346-017-0429-9
DO - 10.1007/s13346-017-0429-9
M3 - Review article
C2 - 28975503
AN - SCOPUS:85053084783
SN - 2190-393X
VL - 8
SP - 740
EP - 759
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 3
ER -