TY - JOUR
T1 - The equine immune responses to infectious and allergic disease
T2 - A model for humans?
AU - Horohov, David W.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The modern horse, Equus caballus has historically made important contributions to the field of immunology, dating back to Emil von Behring's description of curative antibodies in equine serum over a century ago. While the horse continues to play an important role in human serotherapy, the mouse has replaced the horse as the predominant experimental animal in immunology research. Nevertheless, continuing efforts have led to an improved understanding of the equine immune response in a variety of infectious and non-infectious diseases. Based on this information, we can begin to identify specific situations where the horse may provide a unique immunological model for certain human diseases.
AB - The modern horse, Equus caballus has historically made important contributions to the field of immunology, dating back to Emil von Behring's description of curative antibodies in equine serum over a century ago. While the horse continues to play an important role in human serotherapy, the mouse has replaced the horse as the predominant experimental animal in immunology research. Nevertheless, continuing efforts have led to an improved understanding of the equine immune response in a variety of infectious and non-infectious diseases. Based on this information, we can begin to identify specific situations where the horse may provide a unique immunological model for certain human diseases.
KW - Allergy
KW - Equine
KW - Immunity
KW - Infectious disease
UR - http://www.scopus.com/inward/record.url?scp=84925503455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925503455&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2014.09.020
DO - 10.1016/j.molimm.2014.09.020
M3 - Review article
C2 - 25457878
AN - SCOPUS:84925503455
SN - 0161-5890
VL - 66
SP - 89
EP - 96
JO - Molecular Immunology
JF - Molecular Immunology
IS - 1
ER -
