Abstract
Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical role of endoplasmic reticulum (ER) stress-autophagy axis in maintaining cognitive functions and provided pharmacological evidence with respect to cognitive improvements in a diabetic mouse model. These novel findings present new insights into the pathological mechanisms and therapeutic implications with the ER stress modulators in diabetes-related cognitive dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 1255-1258 |
| Number of pages | 4 |
| Journal | Clinical Science |
| Volume | 134 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 12 2020 |
Bibliographical note
© 2020 The Author(s).UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Animals
- Autophagy
- Clinical Trials as Topic
- Cognitive Dysfunction/pathology
- Diabetes Mellitus/pathology
- Endoplasmic Reticulum Stress
- Humans
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