The evolution of platelet-directed pharmacotherapy

R. C. Becker, S. Smyth

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The evolution of platelet directed pharmacotherapy in the prevention and treatment of patients with thrombotic disorders is based soundly on a rapidly expanding knowledge of platelet biology. Traditionally viewed, throughout most of its relatively brief history in medicine, as an anucleate, passive contributor to hemostasis, a more contemporary perspective acknowledges platelets as complex, multidimensional cells that participate actively in coagulation, vascular repair, angiogenesis and thrombosis within the micro and the macro-circulatory systems. Herein, we consider platelet-directed pharmacotherapy from these fundamental, biology-based exemplars-megakaryocytes, signal transduction and the platelet-coagulation protease interface. We also highlight the emerging biopharmacology platform of oligonucleotide platelet adhesion antagonists and their complementary antidotes.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalJournal of Thrombosis and Haemostasis
Issue numberSUPPL. 1
StatePublished - 2009


  • Aptamers
  • Platelet
  • Signal transduction

ASJC Scopus subject areas

  • Hematology


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