TY - JOUR
T1 - The evolutionary advantage of artemisinin production by Artemisia annua
AU - Yin, Qinggang
AU - Xiang, Li
AU - Han, Xiaoyan
AU - Zhang, Yujun
AU - Lyu, Ruiqing
AU - Yuan, Ling
AU - Chen, Shilin
N1 - Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2025/2
Y1 - 2025/2
N2 - Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.
AB - Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.
KW - ADS
KW - ROS
KW - artemisinin biosynthesis
KW - artemisinin metabolism
KW - stress resistance
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U2 - 10.1016/j.tplants.2024.09.006
DO - 10.1016/j.tplants.2024.09.006
M3 - Review article
AN - SCOPUS:85205426917
SN - 1360-1385
VL - 30
SP - 213
EP - 226
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 2
ER -