Abstract
Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.
| Original language | English |
|---|---|
| Pages (from-to) | 213-226 |
| Number of pages | 14 |
| Journal | Trends in Plant Science |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2025 |
Bibliographical note
Publisher Copyright:© 2024 Elsevier Ltd
Funding
This work was supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences (CACMS Innovation Fund, CI2023E005TS06, CI2023E002-Y-32) and by Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ13-YQ-097, ZZ13-YQ-102, ZZ16-ND-10-14, and ZZ17-ND-10-04), and by the National Natural Science Foundation of China (32370389 and 82474038). The authors declare no conflicts of interest. This work was supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences (CACMS Innovation Fund, CI2023E005TS06 , CI2023E002-Y-32 ) and by Fundamental Research Funds for the Central Public Welfare Research Institutes ( ZZ13-YQ-097 , ZZ13-YQ-102 , ZZ16-ND-10-14 , and ZZ17-ND-10-04 );
| Funders | Funder number |
|---|---|
| Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences | |
| China Academy of Chinese Medical Sciences | CI2023E002-Y-32, CI2023E005TS06 |
| China Academy of Chinese Medical Sciences | |
| Fundamental Research Funds for the Central Public Welfare Research Institutes | ZZ13-YQ-097, ZZ16-ND-10-14, ZZ13-YQ-102, ZZ17-ND-10-04 |
| National Natural Science Foundation of China (NSFC) | 82474038, 32370389 |
| National Natural Science Foundation of China (NSFC) |
Keywords
- ADS
- ROS
- artemisinin biosynthesis
- artemisinin metabolism
- stress resistance
ASJC Scopus subject areas
- Plant Science