The evolving landscape of imprinted genes in humans and mice: Conflict among alleles, genes, tissues, and kin

Jon F. Wilkins, Francisco Úbeda, Jeremy Van Cleve

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Three recent genome-wide studies in mice and humans have produced the most definitive map to date of genomic imprinting (gene expression that depends on parental origin) by incorporating multiple tissue types and developmental stages. Here, we explore the results of these studies in light of the kinship theory of genomic imprinting, which predicts that imprinting evolves due to differential genetic relatedness between maternal and paternal relatives. The studies produce a list of imprinted genes with around 120-180 in mice and ∼100 in humans. The studies agree on broad patterns across mice and humans including the complex patterns of imprinted expression at loci like Igf2 and Grb10. We discuss how the kinship theory provides a powerful framework for hypotheses that can explain these patterns. Finally, since imprinting is rare in the genome despite predictions from the kinship theory that it might be common, we discuss evolutionary factors that could favor biallelic expression.

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalBioEssays
Volume38
Issue number5
DOIs
StatePublished - May 1 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY Periodicals, Inc.

Keywords

  • Genome-wide map
  • Genomic imprinting
  • Grb10
  • Igf2
  • Intragenomic conflict
  • Kinship theory
  • RNA-seq

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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