The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease

Michael Y. Aksenov; H. Michael Tucker; Prakash Nair; Marina V. Aksenova; D. Allan Butterfield; Steven Estus; William R. Markesbery

doi:10.1023/A:1020783614031

The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease

Michael Y. Aksenov, H. Michael Tucker, Prakash Nair, Marina V. Aksenova, D. Allan Butterfield, Steven Estus, William R. Markesbery

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.

Original language	English
Pages (from-to)	767-774
Number of pages	8
Journal	Neurochemical Research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1023/A:1020783614031
State	Published - 1999

Bibliographical note

Funding Information:
The authorsthankMs. Paula Thomasonfor assistance in manuscript preparation and Mr. Cecil Runyons for subject demographic data. This work was supportedin part by NIH grantsAG-10836(SE),

Funding Information:
1 PO1-AG05119 (W.R.M.) by a grant from the Abercrombie Foundation (W.R.M.), and a grant from the Kleberg Foundation (W.R.M.).

Funding

The authorsthankMs. Paula Thomasonfor assistance in manuscript preparation and Mr. Cecil Runyons for subject demographic data. This work was supportedin part by NIH grantsAG-10836(SE), 1 PO1-AG05119 (W.R.M.) by a grant from the Abercrombie Foundation (W.R.M.), and a grant from the Kleberg Foundation (W.R.M.).

Funders	Funder number
NIH grantsAG-10836	grantsAG-10836
National Institute on Aging	P01AG005119
Alice Kleberg Reynolds Foundation
Abercrombie Foundation

Keywords

Alzheimer's disease
Cytochrome c oxidase
Gene expression
MRNA
NADH dehydrogenase
RT PCR

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1023/A:1020783614031

Fingerprint

Dive into the research topics of 'The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this

Aksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., & Markesbery, W. R. (1999). The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease. Neurochemical Research, 24(6), 767-774. https://doi.org/10.1023/A:1020783614031

@article{01f2ec4d4d534b51a80961b5e6f7e1b8,

title = "The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease",

abstract = "In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.",

keywords = "Alzheimer's disease, Cytochrome c oxidase, Gene expression, MRNA, NADH dehydrogenase, RT PCR",

author = "Aksenov, {Michael Y.} and Tucker, {H. Michael} and Prakash Nair and Aksenova, {Marina V.} and Butterfield, {D. Allan} and Steven Estus and Markesbery, {William R.}",

note = "Funding Information: The authorsthankMs. Paula Thomasonfor assistance in manuscript preparation and Mr. Cecil Runyons for subject demographic data. This work was supportedin part by NIH grantsAG-10836(SE), Funding Information: 1 PO1-AG05119 (W.R.M.) by a grant from the Abercrombie Foundation (W.R.M.), and a grant from the Kleberg Foundation (W.R.M.).",

year = "1999",

doi = "10.1023/A:1020783614031",

language = "English",

volume = "24",

pages = "767--774",

number = "6",

}

Aksenov, MY, Tucker, HM, Nair, P, Aksenova, MV, Butterfield, DA , Estus, S & Markesbery, WR 1999, 'The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease', Neurochemical Research, vol. 24, no. 6, pp. 767-774. https://doi.org/10.1023/A:1020783614031

The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease. / Aksenov, Michael Y.; Tucker, H. Michael; Nair, Prakash et al.
In: Neurochemical Research, Vol. 24, No. 6, 1999, p. 767-774.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease

AU - Aksenov, Michael Y.

AU - Tucker, H. Michael

AU - Nair, Prakash

AU - Aksenova, Marina V.

AU - Butterfield, D. Allan

AU - Estus, Steven

AU - Markesbery, William R.

N1 - Funding Information: The authorsthankMs. Paula Thomasonfor assistance in manuscript preparation and Mr. Cecil Runyons for subject demographic data. This work was supportedin part by NIH grantsAG-10836(SE), Funding Information: 1 PO1-AG05119 (W.R.M.) by a grant from the Abercrombie Foundation (W.R.M.), and a grant from the Kleberg Foundation (W.R.M.).

PY - 1999

Y1 - 1999

N2 - In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.

AB - In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered proportion between CO II and CO IV mRNAs was observed in the AD brain. Changes of the proportion between CO II and CO IV transcripts may contribute to the kinetic perturbation of CO documented in AD. A coordinated decrease of ND4 and ND15 mRNAs was found in the AD hippocampus and inferior parietal lobule, but not in cerebellum. The decrease of ND4 gene expression may lead to the inhibition of normal ubiquinone oxidoreductase activity of ND. This study suggests that changes of the expression of mitochondrial and nuclear genes, encoding parts of ND and CO enzyme complexes, may contribute to alterations of oxidative metabolism in AD.

KW - Alzheimer's disease

KW - Cytochrome c oxidase

KW - Gene expression

KW - MRNA

KW - NADH dehydrogenase

KW - RT PCR

UR - http://www.scopus.com/inward/record.url?scp=0032971621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032971621&partnerID=8YFLogxK

U2 - 10.1023/A:1020783614031

DO - 10.1023/A:1020783614031

M3 - Article

C2 - 10447460

AN - SCOPUS:0032971621

SN - 0364-3190

VL - 24

SP - 767

EP - 774

JO - Neurochemical Research

JF - Neurochemical Research

IS - 6

ER -

Aksenov MY, Tucker HM, Nair P, Aksenova MV, Butterfield DA , Estus S et al. The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease. Neurochemical Research. 1999;24(6):767-774. doi: 10.1023/A:1020783614031

The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this