Abstract
From its initial isolation in the USA in 2011 to the present, influenza D virus (IDV) has been detected in cattle and swine populations worldwide. IDV has exceptional thermal and acid stability and a broad host range. The virus utilizes cattle as its natural reservoir and amplification host with periodic spillover to other mammalian species, including swine. IDV infection can cause mild to moderate respiratory illnesses in cattle and has been implicated as a contributor to bovine respiratory disease (BRD) complex, which is the most common and costly disease affecting the cattle industry. Bovine and swine IDV outbreaks continue to increase globally, and there is increasing evidence indicating that IDV may have the potential to infect humans. This review discusses recent advances in IDV biology and epidemiology, and summarizes our current understanding of IDV pathogenesis and zoonotic potential.
| Original language | English |
|---|---|
| Article number | 001529 |
| Journal | Journal of General Virology |
| Volume | 102 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Publisher Copyright:© 2021 The Authors
Funding
This study was supported by NIH R01AI141889, SDSU-AES 3AH-673, USDA/NIFA 2016-67016-24949, NSF/EPSCoR (http://www.nsf.gov/od/iia/programs/epscor/index.jsp) award IIA-1335423, the SD-CBRC supported by the State of South Dakota's Governor's Office of Economic Development, University of Kentucky AES, and William Robert Mills endowment fund to University of Kentucky. This study was supported by NIH R01AI141889, SDSU-AES 3AH-673, USDA/NIFA 2016-67016-24949, NSF/EPSCoR (http://www.nsf.gov/ od/iia/programs/epscor/index.jsp) award IIA-1335423, the SD-CBRC supported by the State of South Dakota’s Governor’s Office of Economic Development, University of Kentucky AES, and William Robert Mills endowment fund to University of Kentucky.
| Funders | Funder number |
|---|---|
| SD-CBRC | |
| South Dakota's Governor's Office of Economic Development | |
| South Dakota’s Governor’s Office of Economic Development | |
| National Science Foundation (NSF) | |
| National Institutes of Health (NIH) | USDA/NIFA 2016-67016-24949, SDSU-AES 3AH-673 |
| National Institute of Allergy and Infectious Diseases | R01AI141889 |
| Office of Experimental Program to Stimulate Competitive Research | IIA-1335423 |
| University of Kentucky |
Keywords
- Epidemiology
- Genetic and antigenic evolution
- Influenza D virus
- Pathogenicity
- Zoonotic potential
ASJC Scopus subject areas
- Virology