The function of Shoc2: A scaffold and beyond

Eun Ryoung Jang, Emilia Galperin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions in multicellular organisms. Scaffold proteins provide critical spatial and temporal control over the specificity of signaling. Shoc2 is a scaffold that accelerates activity of the ERK1/2 pathway. Loss of Shoc2 expression in mice results in embryonic lethality, thus highlighting the essential role of Shoc2 in embryogenesis. In agreement, patients carrying mutated Shoc2 suffer from a wide spectrum of developmental deficiencies. Efforts to understand the mechanisms by which Shoc2 controls ERK1/2 activity revealed the intricate machinery that governs the ability of Shoc2 to transduce signals of the ERK1/2 pathway. Understanding the mechanisms by which Shoc2 contributes to a high degree of specificity of ERK1/2 signaling as well as deciphering the biological functions of Shoc2 in development and human disorders are major unresolved questions.

Original languageEnglish
Article numbere1188241
JournalCommunicative and Integrative Biology
Volume9
Issue number4
DOIs
StatePublished - Jul 3 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s). Published with license by Taylor & Francis. © Eun Ryoung Jang and Emilia Galperin.

Keywords

  • ERK1/2
  • scaffold; Shoc2

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (all)

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