The function of Shoc2: A scaffold and beyond

Eun Ryoung Jang, Emilia Galperin

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions in multicellular organisms. Scaffold proteins provide critical spatial and temporal control over the specificity of signaling. Shoc2 is a scaffold that accelerates activity of the ERK1/2 pathway. Loss of Shoc2 expression in mice results in embryonic lethality, thus highlighting the essential role of Shoc2 in embryogenesis. In agreement, patients carrying mutated Shoc2 suffer from a wide spectrum of developmental deficiencies. Efforts to understand the mechanisms by which Shoc2 controls ERK1/2 activity revealed the intricate machinery that governs the ability of Shoc2 to transduce signals of the ERK1/2 pathway. Understanding the mechanisms by which Shoc2 contributes to a high degree of specificity of ERK1/2 signaling as well as deciphering the biological functions of Shoc2 in development and human disorders are major unresolved questions.

Original languageEnglish
Article numbere1188241
JournalCommunicative and Integrative Biology
Issue number4
StatePublished - Jul 3 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s). Published with license by Taylor & Francis. © Eun Ryoung Jang and Emilia Galperin.


  • ERK1/2
  • scaffold; Shoc2

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences


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