The future of aminoglycosides: The end or renaissance?

Jacob L. Houghton, Keith D. Green, Wenjing Chen, Sylvie Garneau-Tsodikova

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations

Abstract

(Figure Presented) Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.

Original languageEnglish
Pages (from-to)880-902
Number of pages23
JournalChemBioChem
Volume11
Issue number7
DOIs
StatePublished - May 3 2010

Keywords

  • Aminoglycosides
  • Antibiotics
  • Antiviral agents
  • Chemoenzymatic synthesis
  • Drug resistance
  • Genetic diseases

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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