The genome sequence of the rice blast fungus Magnaporthe grisea

Ralph A. Dean, Nicholas J. Talbot, Daniel J. Ebbole, Mark L. Farman, Thomas K. Mitchell, Marc J. Orbach, Michael Thon, Resham Kulkarni, Jin Rong Xu, Huaqin Pan, Nick D. Read, Yong Ilwan Lee, Ignazio Carbone, Doug Brown, Yee Oh Yeon, Nicole Donofrio, Seop Jeong Jun, Darren M. Soanes, Slavica Djonovic, Elena KolomlotsCathryn Rehmeyer, Weixl Li, Michael Harding, Soonok Kim, Marc Henri Lebrun, Heidi Bohnert, Sean Coughlan, Jonathan Butler, Sarah Calvo, Li Jun Ma, Robert Nicol, Seth Purcell, Chad Nusbaum, James E. Galagan, Bruce W. Dirren

Research output: Contribution to journalArticlepeer-review

1249 Scopus citations


Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.

Original languageEnglish
Pages (from-to)980-986
Number of pages7
Issue number7036
StatePublished - Apr 21 2005

Bibliographical note

Funding Information:
Acknowledgements The authors acknowledge the USDA-CSREES and the National Science Foundation for funding this work. We thank all the members of the Dean Laboratory at NCSU, and members of the Broad Institute Sequencing Platform, Assembly and Annotation teams, and members at each collaborating laboratory. We also thank the rice blast research community at large. We acknowledge other fungal research communities, in particular the A. nidulans community, for making it possible to have access to genome sequence information before publication.

ASJC Scopus subject areas

  • General


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