TY - JOUR
T1 - The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers
AU - Dürr, Clemens
AU - Hoffmeister, Dirk
AU - Wohlert, Sven Eric
AU - Ichinose, Koji
AU - Weber, Monika
AU - Von Mulert, Ursula
AU - Thorson, Jon S.
AU - Bechthold, Andreas
PY - 2004/5/24
Y1 - 2004/5/24
N2 - Sweet success: A natural product glycosyltransferase, UrdGT2 from Streptomyces fradiae Tü2717, is the first glycosyltransferase able to catalyze both C-glycosidic and O-glycosidic sugar transfers. These results shed new light on the mechanisms of C-glycosylation of aromatic compounds, which is significant for chemoenzymatic drug lead derivatization as well as for enzymology.
AB - Sweet success: A natural product glycosyltransferase, UrdGT2 from Streptomyces fradiae Tü2717, is the first glycosyltransferase able to catalyze both C-glycosidic and O-glycosidic sugar transfers. These results shed new light on the mechanisms of C-glycosylation of aromatic compounds, which is significant for chemoenzymatic drug lead derivatization as well as for enzymology.
KW - Drug design
KW - Glycosylation
KW - Glycosyltransferases
KW - Natural products
KW - Streptomycetes
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U2 - 10.1002/anie.200453758
DO - 10.1002/anie.200453758
M3 - Article
C2 - 15170316
AN - SCOPUS:4544291468
SN - 1433-7851
VL - 43
SP - 2962
EP - 2965
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 22
ER -