TY - JOUR
T1 - The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014
T2 - a global, population-based study (CONCORD-3)
AU - Girardi, Fabio
AU - Rous, Brian
AU - Stiller, Charles A.
AU - Gatta, Gemma
AU - Fersht, Naomi
AU - Storm, Hans H.
AU - Rodrigues, Jessica R.
AU - Herrmann, Christian
AU - Marcos-Gragera, Rafael
AU - Peris-Bonet, Rafael
AU - Valkov, Mikhail
AU - Weir, Hannah K.
AU - Woods, Ryan R.
AU - You, Hui
AU - Cueva, Patricia A.
AU - De, Prithwish
AU - Di Carlo, Veronica
AU - Johannesen, Tom Børge
AU - Lima, Carlos A.
AU - Lynch, Charles F.
AU - Coleman, Michel P.
AU - Allemani, Claudia
AU - Bouzbid, S.
AU - Hamdi-Chérif, M.
AU - Zaidi, Z.
AU - Meguenni, K.
AU - Regagba, D.
AU - Bayo, S.
AU - Cheick Bougadari, T.
AU - Manraj, S. S.
AU - Bendahhou, K.
AU - Ladipo, A.
AU - Ogunbiyi, O. J.
AU - Ramaliba, T.
AU - Somdyala, N. I.M.
AU - Chaplin, M. A.
AU - Moreno, F.
AU - Calabrano, G. H.
AU - Espinola, S. B.
AU - Carballo Quintero, B.
AU - Fita, R.
AU - Laspada, W. D.
AU - Ibañez, S. G.
AU - Mafra da Costa, A.
AU - De Souza, P. C.F.
AU - Del Pino, K.
AU - Laporte, C.
AU - Curado, M. P.
AU - Huang, B.
AU - Tucker, T. C.
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background: Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods: The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. Results: Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. Conclusions: To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
AB - Background: Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods: The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. Results: Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. Conclusions: To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
KW - International Classification of Diseases
KW - epidemiological study
KW - health care disparities
KW - histology
KW - population-based cancer registries
KW - primary brain tumor
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U2 - 10.1093/neuonc/noab067
DO - 10.1093/neuonc/noab067
M3 - Review article
C2 - 33738488
AN - SCOPUS:85106923396
SN - 1522-8517
VL - 23
SP - 1765
EP - 1776
JO - Neuro-Oncology
JF - Neuro-Oncology
IS - 10
ER -
