Because of the high prevalence of subsequent posttraumatic osteoarthritis (PTOA), anterior cruciate ligament (ACL) injury has been adopted as a human model of early osteoarthritis. There are multiple mechanisms by which ACL injury promotes PTOA progression. The injury affects the joint as an organ impacting not only the articular cartilage but also the synovium, underlying bone, and surrounding musculature with similar pathways implicated in the development and progression of idiopathic knee OA. In addition, both patient and injury characteristics may also contribute to PTOA progression after ACL injury.
|Title of host publication||Early Osteoarthritis|
|Subtitle of host publication||State-of-the-Art Approaches to Diagnosis, Treatment and Controversies|
|Number of pages||9|
|State||Published - Jan 1 2021|
Bibliographical notePublisher Copyright:
© ISAKOS 2022.
- Posttraumatic osteoarthritis
ASJC Scopus subject areas
- Medicine (all)
- Health Professions (all)