The Human Anterior Cruciate Ligament Injury Model of Early Osteoarthritis

Cale A. Jacobs; Emily R. Hunt

doi:10.1007/978-3-030-79485-9_7

The Human Anterior Cruciate Ligament Injury Model of Early Osteoarthritis

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Because of the high prevalence of subsequent posttraumatic osteoarthritis (PTOA), anterior cruciate ligament (ACL) injury has been adopted as a human model of early osteoarthritis. There are multiple mechanisms by which ACL injury promotes PTOA progression. The injury affects the joint as an organ impacting not only the articular cartilage but also the synovium, underlying bone, and surrounding musculature with similar pathways implicated in the development and progression of idiopathic knee OA. In addition, both patient and injury characteristics may also contribute to PTOA progression after ACL injury.

Original language	English
Title of host publication	Early Osteoarthritis
Subtitle of host publication	State-of-the-Art Approaches to Diagnosis, Treatment and Controversies
Pages	73-81
Number of pages	9
ISBN (Electronic)	9783030794859
DOIs	https://doi.org/10.1007/978-3-030-79485-9_7
State	Published - Jan 1 2021

Bibliographical note

Publisher Copyright:
© ISAKOS 2022.

Keywords

Bone
Inflammation
Meniscus
Muscle
Posttraumatic osteoarthritis

ASJC Scopus subject areas

Medicine (all)
Health Professions (all)

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10.1007/978-3-030-79485-9_7

Cite this

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abstract = "Because of the high prevalence of subsequent posttraumatic osteoarthritis (PTOA), anterior cruciate ligament (ACL) injury has been adopted as a human model of early osteoarthritis. There are multiple mechanisms by which ACL injury promotes PTOA progression. The injury affects the joint as an organ impacting not only the articular cartilage but also the synovium, underlying bone, and surrounding musculature with similar pathways implicated in the development and progression of idiopathic knee OA. In addition, both patient and injury characteristics may also contribute to PTOA progression after ACL injury.",

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AB - Because of the high prevalence of subsequent posttraumatic osteoarthritis (PTOA), anterior cruciate ligament (ACL) injury has been adopted as a human model of early osteoarthritis. There are multiple mechanisms by which ACL injury promotes PTOA progression. The injury affects the joint as an organ impacting not only the articular cartilage but also the synovium, underlying bone, and surrounding musculature with similar pathways implicated in the development and progression of idiopathic knee OA. In addition, both patient and injury characteristics may also contribute to PTOA progression after ACL injury.

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The Human Anterior Cruciate Ligament Injury Model of Early Osteoarthritis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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