The Human Anterior Cruciate Ligament Injury Model of Early Osteoarthritis

Cale A. Jacobs, Emily R. Hunt

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Because of the high prevalence of subsequent posttraumatic osteoarthritis (PTOA), anterior cruciate ligament (ACL) injury has been adopted as a human model of early osteoarthritis. There are multiple mechanisms by which ACL injury promotes PTOA progression. The injury affects the joint as an organ impacting not only the articular cartilage but also the synovium, underlying bone, and surrounding musculature with similar pathways implicated in the development and progression of idiopathic knee OA. In addition, both patient and injury characteristics may also contribute to PTOA progression after ACL injury.

Original languageEnglish
Title of host publicationEarly Osteoarthritis
Subtitle of host publicationState-of-the-Art Approaches to Diagnosis, Treatment and Controversies
Number of pages9
ISBN (Electronic)9783030794859
StatePublished - Jan 1 2021

Bibliographical note

Publisher Copyright:
© ISAKOS 2022.


  • Bone
  • Inflammation
  • Meniscus
  • Muscle
  • Posttraumatic osteoarthritis

ASJC Scopus subject areas

  • Medicine (all)
  • Health Professions (all)


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