The identification of perillyl alcohol glycosides with improved antiproliferative activity

Nitin S. Nandurkar, Jianjun Zhang, Qing Ye, Larissa V. Ponomareva, Qing Bai She, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4′-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date.

Original languageEnglish
Pages (from-to)7478-7484
Number of pages7
JournalJournal of Medicinal Chemistry
Volume57
Issue number17
DOIs
StatePublished - Sep 11 2014

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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