Abstract
A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4′-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date.
Original language | English |
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Pages (from-to) | 7478-7484 |
Number of pages | 7 |
Journal | Journal of Medicinal Chemistry |
Volume | 57 |
Issue number | 17 |
DOIs | |
State | Published - Sep 11 2014 |
Bibliographical note
Publisher Copyright:© 2014 American Chemical Society.
Funding
Funders | Funder number |
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National Center for Advancing Translational Sciences (NCATS) | UL1TR000117 |
National Institutes of Health (NIH) | R37 AI52218 |
National Institute of Allergy and Infectious Diseases | R37AI052218 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery