The immunopharmacological properties of transforming growth factor beta

Yingying Le; Xiaojing Yu; Lingfei Ruan; Oumei Wang; Dongfei Qi; Jingjing Zhu; Xiaofeng Lu; Yan Kong; Kun Cai; Shanshan Pang; Xianglin Shi; Ji Ming Wang

doi:10.1016/j.intimp.2005.07.006

The immunopharmacological properties of transforming growth factor beta

Yingying Le, Xiaojing Yu, Lingfei Ruan, Oumei Wang, Dongfei Qi, Jingjing Zhu, Xiaofeng Lu, Yan Kong, Kun Cai, Shanshan Pang, Xianglin Shi, Ji Ming Wang

Toxicology and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.

Original language	English
Pages (from-to)	1771-1782
Number of pages	12
Journal	International Immunopharmacology
Volume	5
Issue number	13-14
DOIs	https://doi.org/10.1016/j.intimp.2005.07.006
State	Published - Dec 2005

Keywords

Alzheimer's disease
Inflammation
Transforming growth factor beta

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1016/j.intimp.2005.07.006

Cite this

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title = "The immunopharmacological properties of transforming growth factor beta",

abstract = "Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.",

keywords = "Alzheimer's disease, Inflammation, Transforming growth factor beta",

author = "Yingying Le and Xiaojing Yu and Lingfei Ruan and Oumei Wang and Dongfei Qi and Jingjing Zhu and Xiaofeng Lu and Yan Kong and Kun Cai and Shanshan Pang and Xianglin Shi and Wang, {Ji Ming}",

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language = "English",

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T1 - The immunopharmacological properties of transforming growth factor beta

AU - Le, Yingying

AU - Yu, Xiaojing

AU - Ruan, Lingfei

AU - Wang, Oumei

AU - Qi, Dongfei

AU - Zhu, Jingjing

AU - Lu, Xiaofeng

AU - Kong, Yan

AU - Cai, Kun

AU - Pang, Shanshan

AU - Shi, Xianglin

AU - Wang, Ji Ming

PY - 2005/12

Y1 - 2005/12

N2 - Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.

AB - Transforming growth factor-β (TGF-β) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. These events are closely associated with host immune responses and inflammation. Despite some controversies on their function in controlling dendritic and T regulatory cell development and activity, the importance of TGF-βs in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. Since one of the major biological properties of TGF-βs is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions.

KW - Alzheimer's disease

KW - Inflammation

KW - Transforming growth factor beta

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The immunopharmacological properties of transforming growth factor beta

Abstract

Keywords

ASJC Scopus subject areas

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