The immunoproteasome: An emerging therapeutic target

Wooin Lee, Kyung Bo Kim

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The proteasome, a large multisubunit protease complex, has been extensively investigated over the years, greatly enhancing our understanding of critical roles that the proteasome plays in cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has validated the proteasome as an anticancer target. However, the undesirable toxicities of these agents limit their broad utility. The immunoproteasome, an alternative form of the constitutive proteasome, has recently been explored as a therapeutic target. While the immunoproteasome, normally expressed in cells of hematopoietic origin, has been shown to be associated with various types of cancer and inflammatory diseases, its multifaceted function is not fully understood due to the lack of appropriate molecular probes. In this review, recent advances in the immunoproteasome field are covered, including potential implications in disease states. In particular, recent developments in immunoproteasome-specific inhibitors are emphasized.

Original languageEnglish
Pages (from-to)2923-2930
Number of pages8
JournalCurrent Topics in Medicinal Chemistry
Volume11
Issue number23
DOIs
StatePublished - Dec 2011

Keywords

  • Cancer
  • Degenerative disease
  • Immunoproteasome
  • Inhibitor
  • Protein degradation

ASJC Scopus subject areas

  • Drug Discovery

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