The impact of cellular senescence in cancer therapy: Is it true or not?

Yi Zhang, Jin Ming Yang

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Cellular senescence is defined as the physiological program of terminal growth arrest, which can be triggered by various endogenous or exogenous stress signals. Cellular senescence can be induced in response to oncogenic activation and acts as a barrier to tumorigenesis. Moreover, tumor cells can undergo senescence when exposed to chemotherapeutic agents. In addition to suppressing tumorigenesis, senescent cells remain metabolically active and may contribute to tumor formation and to therapy resistance. In the current review, we discuss the molecular regulation of cellular senescence, the potential implications of senescence in human cancers, and the possibility of exploiting cellular senescence for the treatment of cancers.

Original languageEnglish
Pages (from-to)1199-1207
Number of pages9
JournalActa Pharmacologica Sinica
Issue number10
StatePublished - Oct 2011


  • cancer therapy
  • cell death
  • cell survival
  • oncogenesis
  • senescence

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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