The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer

Zobeida Cruz-Monserrate, Darwin L. Conwell, Somashekar G. Krishna

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.

Original languageEnglish
Pages (from-to)625-637
Number of pages13
JournalGastroenterology Clinics of North America
Issue number4
StatePublished - Dec 1 2016

Bibliographical note

Funding Information:
Grant Support: This publication was supported (D.L. Conwell) by the National Institutes of Diabetes and Digestive and Kidney Diseases and National Cancer Institute under Award Number U01DK108327 .

Publisher Copyright:
© 2016 Elsevier Inc.


  • Gallstone disease
  • Obesity
  • Pancreatic cancer
  • Pancreatitis

ASJC Scopus subject areas

  • Gastroenterology


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