The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer

Zobeida Cruz-Monserrate; Darwin L. Conwell; Somashekar G. Krishna

doi:10.1016/j.gtc.2016.07.010

The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer

Zobeida Cruz-Monserrate, Darwin L. Conwell, Somashekar G. Krishna

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.

Original language	English
Pages (from-to)	625-637
Number of pages	13
Journal	Gastroenterology Clinics of North America
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.gtc.2016.07.010
State	Published - Dec 1 2016

Bibliographical note

Funding Information:
Grant Support: This publication was supported (D.L. Conwell) by the National Institutes of Diabetes and Digestive and Kidney Diseases and National Cancer Institute under Award Number U01DK108327 .

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Gallstone disease
Obesity
Pancreatic cancer
Pancreatitis

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.gtc.2016.07.010

Cite this

@article{6683ba695e2248bba96e99eac0326847,

title = "The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer",

abstract = "Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.",

keywords = "Gallstone disease, Obesity, Pancreatic cancer, Pancreatitis",

author = "Zobeida Cruz-Monserrate and Conwell, {Darwin L.} and Krishna, {Somashekar G.}",

note = "Funding Information: Grant Support: This publication was supported (D.L. Conwell) by the National Institutes of Diabetes and Digestive and Kidney Diseases and National Cancer Institute under Award Number U01DK108327 . Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.gtc.2016.07.010",

language = "English",

volume = "45",

pages = "625--637",

journal = "Gastroenterology Clinics of North America",

issn = "0889-8553",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer

AU - Cruz-Monserrate, Zobeida

AU - Conwell, Darwin L.

AU - Krishna, Somashekar G.

N1 - Funding Information: Grant Support: This publication was supported (D.L. Conwell) by the National Institutes of Diabetes and Digestive and Kidney Diseases and National Cancer Institute under Award Number U01DK108327 . Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.

AB - Obesity is a well-recognized risk factor for gallstone formation and increases the risk for gallstone-related complications. Pancreatic diseases are impacted adversely by obesity. Although weight loss surgery increases the risk of gallstone disease, evidence suggests that bariatric surgery mitigates the obesity-associated adverse prognostication in acute pancreatitis. Obesity is also a significant risk factor for pancreatic cancer. Obesity is a global epidemic and is increasing worldwide and among all age groups. There is an urgent need for focused health policies aimed at reducing the incidence and prevalence of obesity. This article summarizes the current literature highlighting the association between obesity and the pathophysiology and outcome of gallstone disease, pancreatitis, and pancreatic cancer.

KW - Gallstone disease

KW - Obesity

KW - Pancreatic cancer

KW - Pancreatitis

UR - http://www.scopus.com/inward/record.url?scp=84995459514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995459514&partnerID=8YFLogxK

U2 - 10.1016/j.gtc.2016.07.010

DO - 10.1016/j.gtc.2016.07.010

M3 - Review article

C2 - 27837777

AN - SCOPUS:84995459514

SN - 0889-8553

VL - 45

SP - 625

EP - 637

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

IS - 4

ER -

The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic Cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this