The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

Qing Wang; Hsin Sheng Yang

doi:10.3390/ph17101396

The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

Research output: Contribution to journal › Review article › peer-review

Abstract

Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

Original language	English
Article number	1396
Journal	Pharmaceuticals
Volume	17
Issue number	10
DOIs	https://doi.org/10.3390/ph17101396
State	Published - Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

doxorubicin
eIF4A
fluorouracil
IGF1R/IR inhibitor
JNK pathway
mTORC2–Akt pathway
paclitaxel
platinum-containing drug
β-catenin pathway

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

Access to Document

10.3390/ph17101396

Cite this

@article{eacd0dfc0ce84bc9b4b4ac554f05c761,

title = "The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance",

abstract = "Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.",

keywords = "doxorubicin, eIF4A, fluorouracil, IGF1R/IR inhibitor, JNK pathway, mTORC2–Akt pathway, paclitaxel, platinum-containing drug, β-catenin pathway",

author = "Qing Wang and Yang, {Hsin Sheng}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = oct,

doi = "10.3390/ph17101396",

language = "English",

volume = "17",

number = "10",

}

TY - JOUR

T1 - The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

AU - Wang, Qing

AU - Yang, Hsin Sheng

PY - 2024/10

Y1 - 2024/10

N2 - Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

AB - Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

KW - doxorubicin

KW - eIF4A

KW - fluorouracil

KW - IGF1R/IR inhibitor

KW - JNK pathway

KW - mTORC2–Akt pathway

KW - paclitaxel

KW - platinum-containing drug

KW - β-catenin pathway

UR - http://www.scopus.com/inward/record.url?scp=85207661443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85207661443&partnerID=8YFLogxK

U2 - 10.3390/ph17101396

DO - 10.3390/ph17101396

M3 - Review article

AN - SCOPUS:85207661443

SN - 1424-8247

VL - 17

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 10

M1 - 1396

ER -

The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this