TY - JOUR
T1 - The importance of translationally evaluating steroid hormone contributions to substance use
AU - Maher, Erin E.
AU - Strzelecki, Ashley M.
AU - Weafer, Jessica J.
AU - Gipson, Cassandra D.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/4
Y1 - 2023/4
N2 - Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical need to study women-specific factors that may influence aspects of SUDs, which may play important roles in addiction processes in a sex-specific fashion. It is important to understand factors that impact women's health and may be key to moving the field forward toward more efficacious and individualized treatment strategies.
AB - Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical need to study women-specific factors that may influence aspects of SUDs, which may play important roles in addiction processes in a sex-specific fashion. It is important to understand factors that impact women's health and may be key to moving the field forward toward more efficacious and individualized treatment strategies.
KW - Contraceptive hormones
KW - Estrogen
KW - Menstrual cycle
KW - Neurobiology
KW - Progesterone
KW - Substance use disorder
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U2 - 10.1016/j.yfrne.2023.101059
DO - 10.1016/j.yfrne.2023.101059
M3 - Article
C2 - 36758769
AN - SCOPUS:85148339505
SN - 0091-3022
VL - 69
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
M1 - 101059
ER -