The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification

Changsheng Zhang, Qiang Fu, Christoph Albermann, Lingjun Li, Jon S. Thorson

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

(Chemical Equation Presented) By capitalizing upon the reversibility of glycosyltransferase-catalyzed reactions, EryBV was characterized in vitro as the erythromycin mycarosyltransferase and the EryBV substrate specificity was investigated. Two-GT (EryBV/AveBI) aglycon-exchange reactions also led to the production of novel hybrid "erythromycin-avermectin" macrolides.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalChemBioChem
Volume8
Issue number4
DOIs
StatePublished - Mar 5 2007

Keywords

  • Biosynthesis
  • Carbohydrates
  • Catalysis
  • Glycosyltransferases
  • Natural products

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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