TY - JOUR
T1 - The Inflamma-type
T2 - a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture
AU - Jacobs, Cale A.
AU - Olsen, Zachary M.
AU - Marchand, Lucas S.
AU - Kraus, Virginia B.
AU - Anderson, Donald D.
AU - Haller, Justin
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2023/1
Y1 - 2023/1
N2 - Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.
AB - Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.
KW - Ankle
KW - Cytokine
KW - Fracture
KW - Inflammation
KW - Knee
KW - Tibia
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U2 - 10.1007/s00011-022-01661-4
DO - 10.1007/s00011-022-01661-4
M3 - Article
C2 - 36309627
AN - SCOPUS:85140838068
SN - 1023-3830
VL - 72
SP - 9
EP - 11
JO - Inflammation Research
JF - Inflammation Research
IS - 1
ER -