The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture

Cale A. Jacobs; Zachary M. Olsen; Lucas S. Marchand; Virginia B. Kraus; Donald D. Anderson; Justin Haller

doi:10.1007/s00011-022-01661-4

The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture

Cale A. Jacobs, Zachary M. Olsen, Lucas S. Marchand, Virginia B. Kraus, Donald D. Anderson, Justin Haller

Research output: Contribution to journal › Article › peer-review

Abstract

Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.

Original language	English
Pages (from-to)	9-11
Number of pages	3
Journal	Inflammation Research
Volume	72
Issue number	1
DOIs	https://doi.org/10.1007/s00011-022-01661-4
State	Published - Jan 2023

Bibliographical note

Funding Information:
Portions of this project were funded by a grant through the Arthritis Foundation’s Osteoarthritis-Clinical Trial Network.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Keywords

Ankle
Cytokine
Fracture
Inflammation
Knee
Tibia

ASJC Scopus subject areas

Immunology
Pharmacology

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10.1007/s00011-022-01661-4

Cite this

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title = "The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture",

abstract = "Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multiplex assays. A cluster analysis of synovial fluid biomarker concentrations was performed. Patient demographics, fracture type, Injury Severity Score (ISS), Charlson Comorbidity Index (CCI), and biomarker concentrations were compared between clusters. A subset of patients demonstrated a dysregulated inflammatory response after articular fracture including elevated pro-inflammatory cytokines and degradative enzymes previously linked to the development of post-traumatic osteoarthritis.",

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AU - Kraus, Virginia B.

AU - Anderson, Donald D.

AU - Haller, Justin

N1 - Funding Information: Portions of this project were funded by a grant through the Arthritis Foundation’s Osteoarthritis-Clinical Trial Network. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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KW - Knee

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The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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