TY - JOUR
T1 - The influence of induced hypertension in acute phase on focal cerebral ischemia injury
AU - Jia, Jian Ping
AU - Jiao, Li Dong
AU - Zhou, Ji Ying
AU - Zhao, Hong Bo
PY - 2005/7/13
Y1 - 2005/7/13
N2 - Objective: To study the influence of induced hypertension in acute phase on the infarct volume and regional cerebral blood flow(rCBF) during focal cerebral ischemia in rats. Methods: The adult rat's models of permanent focal cerebral ischemia were established by permanent middle artery occlusion. Thirty-six rats were divided six groups. The rCBF of cortical penumbra during focal cerebral ischemia was determined by Laser-Doppler Flowmetry. After experiment was over, the brain was TYC stained and the infarct bolume was calculated by computer image analytic system. Results: The rCBF was resumed by (81.8 ± 3.1) %, (56.0 ± 2. 1) % Chinese source. (38.8 ± 2. 0) % in induced hypertension groups compared with the basic rCBF. The Volume of infarction was (14 ± 7) mm3, (90 ± 24) mm3 seperately in group induced hypertension after 2 and 3 hour ischemia. Induced hypertension during 3 hours could reduce infarct volume significantly. Conclusion: To improve rCBF in penumbra may be one of protective mechanism of induced hypertension on brain ischemia.
AB - Objective: To study the influence of induced hypertension in acute phase on the infarct volume and regional cerebral blood flow(rCBF) during focal cerebral ischemia in rats. Methods: The adult rat's models of permanent focal cerebral ischemia were established by permanent middle artery occlusion. Thirty-six rats were divided six groups. The rCBF of cortical penumbra during focal cerebral ischemia was determined by Laser-Doppler Flowmetry. After experiment was over, the brain was TYC stained and the infarct bolume was calculated by computer image analytic system. Results: The rCBF was resumed by (81.8 ± 3.1) %, (56.0 ± 2. 1) % Chinese source. (38.8 ± 2. 0) % in induced hypertension groups compared with the basic rCBF. The Volume of infarction was (14 ± 7) mm3, (90 ± 24) mm3 seperately in group induced hypertension after 2 and 3 hour ischemia. Induced hypertension during 3 hours could reduce infarct volume significantly. Conclusion: To improve rCBF in penumbra may be one of protective mechanism of induced hypertension on brain ischemia.
KW - Focal cerebral ischemia
KW - Induced hypertension
KW - Regional cerebral blood flow
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M3 - Article
C2 - 16253184
AN - SCOPUS:22744445048
SN - 0376-2491
VL - 85
SP - 1813
EP - 1815
JO - National Medical Journal of China
JF - National Medical Journal of China
IS - 26
ER -