The ins and outs of endocytic trafficking in platelet functions

Meenakshi Banerjee, Sidney W. Whiteheart

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Although platelet endocytosis has been recognized in granule cargo loading and the trafficking of several platelet surface receptors, its acute physiological relevance is poorly understood as is its mechanism. The present review discusses the current understanding of platelet endocytosis and its implications for platelet function. Recent findings Recent studies are beginning to identify and define the proteins that mediate platelet endocytosis. These studies have shown that platelets contain different endosomal compartments and may use multiple endocytic routes to take in circulating molecules and surface proteins. The studies have also shown that platelet endocytosis is involved in several aspects of platelet function such as signaling, spreading, and granule cargo loading. Summary Mechanistic studies of platelet endocytosis have shown it to be not only involved in granule cargo loading but also in various other platelet functions important for hemostasis and beyond.

Original languageEnglish
Pages (from-to)467-474
Number of pages8
JournalCurrent Opinion in Hematology
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc.

Funding

FundersFunder number
National Heart, Lung, and Blood Institute (NHLBI)R01HL056652

    Keywords

    • cargo trafficking
    • endosomes
    • pinocytosis
    • receptor-mediated

    ASJC Scopus subject areas

    • Hematology

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