The intersection between DNA damage response and cell death pathways

S. Nowsheen, E. S. Yang

Research output: Contribution to journalReview articlepeer-review

194 Scopus citations

Abstract

Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled "Apoptosis: Four Decades Later".

Original languageEnglish
Pages (from-to)243-254
Number of pages12
JournalExperimental Oncology
Volume34
Issue number3
StatePublished - Sep 2012

Keywords

  • Apoptosis
  • BRCA1
  • Balance between cell survival and death
  • DNA damage and repair
  • EGFR
  • GSK3
  • Poly(ADP-ribose) polymerase
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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