TY - JOUR
T1 - The juvenile hormone signaling pathway in insect development
AU - Jindra, Marek
AU - Palli, Subba R.
AU - Riddiford, Lynn M.
PY - 2013/1/7
Y1 - 2013/1/7
N2 - The molecular action of juvenile hormone (JH), a regulator of vital importance to insects, was until recently regarded as a mystery. The past few years have seen an explosion of studies of JH signaling, sparked by a finding that a JH-resistance gene, Methoprene-tolerant (Met), plays a critical role in insect metamorphosis. Here, we summarize the recently acquired knowledge on the capacity of Met to bind JH, which has been mapped to a particular ligand-binding domain, thus establishing this bHLH-PAS protein as a novel type of an intracellular hormone receptor. Next, we consider the significance of JH-dependent interactions of Met with other transcription factors and signaling pathways. We examine the regulation and biological roles of genes acting downstream of JH and Met in insect metamorphosis. Finally, we discuss the current gaps in our understanding of JH action and outline directions for future research.
AB - The molecular action of juvenile hormone (JH), a regulator of vital importance to insects, was until recently regarded as a mystery. The past few years have seen an explosion of studies of JH signaling, sparked by a finding that a JH-resistance gene, Methoprene-tolerant (Met), plays a critical role in insect metamorphosis. Here, we summarize the recently acquired knowledge on the capacity of Met to bind JH, which has been mapped to a particular ligand-binding domain, thus establishing this bHLH-PAS protein as a novel type of an intracellular hormone receptor. Next, we consider the significance of JH-dependent interactions of Met with other transcription factors and signaling pathways. We examine the regulation and biological roles of genes acting downstream of JH and Met in insect metamorphosis. Finally, we discuss the current gaps in our understanding of JH action and outline directions for future research.
KW - Drosophila
KW - Krüppel-homolog
KW - Methoprene-tolerant
KW - Tribolium
KW - broad
KW - ecdysone
KW - metamorphosis
UR - http://www.scopus.com/inward/record.url?scp=84873056032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873056032&partnerID=8YFLogxK
U2 - 10.1146/annurev-ento-120811-153700
DO - 10.1146/annurev-ento-120811-153700
M3 - Review article
C2 - 22994547
AN - SCOPUS:84873056032
SN - 0066-4170
VL - 58
SP - 181
EP - 204
JO - Annual Review of Entomology
JF - Annual Review of Entomology
ER -