The L-type calcium channel current modulation mechanism: The plot thickens and fogs

Brooke M. Ahern, Jonathan Satin

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Stressful situations provoke the fight-or-flight response, incurring rapid elevation of cardiac output via activation of protein kinase A (PKA). In this issue of the JCI, Yang et al. focus on the L-type calcium channel complex (LTCC), and their findings require reexamination of dogmatic principles. LTCC phosphorylation sites identified and studied to date are dispensable for PKA modulation of LTCC; however, a Ca V β 2 -Ca V 1.2 calcium channel interaction is now shown to be required. Yang et al. suggest a new hypothesis that LTCC modulation involves rearrangement of auxiliary proteins within the LTCC. However, we still do not know the targets of PKA that mediate LTCC modulation.

Original languageEnglish
Pages (from-to)496-498
Number of pages3
JournalJournal of Clinical Investigation
Volume129
Issue number2
DOIs
StatePublished - Feb 1 2019

Bibliographical note

Publisher Copyright:
© 2018 American Society for Clinical Investigation.All right reserved.

ASJC Scopus subject areas

  • General Medicine

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